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US Patent Granted For A Novel Herbal Dressing


Patent No.:
US 10, 076, 552 B2
Date of the Patent Granted: Sep. 18, 2018
Title of the Patent: MULTIFUNCTIONAL FORMULATION COMPRISED OF NATURAL INGREDIENTS AND METHOD OF PREPARATION MANUFACTURING THEREOF

What is Wound Healing & need of the Invention:
Wound Healing is a complex process in which the injured tissue is repaired & regenerated and new tissues are formed. The whole process involves three different phases: inflammation, proliferative and remodeling. Each of these phases is controlled and regulated by biologically active substances called growth factors.

These growth factors are hormone-like molecules that interact with specific cell surface receptors to control the process of tissue repair. The research shows that re-epithelialization is enhanced by the presence of occlusive wound dressings which maintain a moisture barrier.

There are different treatment modalities available for the treatment of wounds and ulcers ranging from antibiotics, occlusive layers, bandages, poultices, mechanical devices that reduce evaporation of water and many others.

The major drawback of these treatment methods is that they enhance wound healing by supporting the body mechanisms to heal the wound. If the patient will have compromised immunity or other body functions that may not work optimally, wound healing will not take place or will be delayed. This may limit the mobility of the patient and lower the quality of life.

There is a need of the treatment method which could actively regenerate the skin, dermis and epidermis. We @ Datt Mediproducts have developed an innovative herbal based antimicrobial dressing which reduce the microflora in wounds and actively promotes healing by stimulating stem cells that are present even in deep wounds and enhance the migration of fibroblast and keratinocytes and secretion of growth factors.

ABOUT THE INVENTION:
The invention involves polymer chemistry and herbal formulation preparation for the treatment of compromised tissues like infected wounds, burn wounds and ulcers in both humans and animals. It is used as a topical device for a range of indications including anti – cancer transdermal patch for melanoma therapy, superbugs infected tropical wounds and multiple sclerosis also.

The invention is composed of a water solubilized nano-sized formulation of a non-aqueous extract of phyto-pharmaceuticals, animal or synthetic biocompatible gel or on matrix coated or both.

 SUMMARY OF THE INVENTION:
The present invention provides a wound healing matrix comprising of a variety of natural ingredients, all working together in a synergistic way to promote wound healing by stimulating the stem cells. Stem cells have a great potential of cell division and are ultimately responsible for the homeostasis of steady state tissues.

Stem cells are normally slow cycling. However, there proliferation can be stimulated by certain growth factors. For example, cytokines such as Tumor Necrosis Factor (TNF), Epidermal Growth Factor (EGF), Transforming Growth Factor (TGF) and Interleukin-1 (IL-1) are believed to be useful.

The present invention consists of different herbs and synthetic biopolymers which are helpful in relieving pain, providing a soothing effect, and healing the wounds upon repeated use by providing a moist healing environment and stimulating the stem cells to regenerate the lost tissues.

The transdermal patch formulated with phytopharmaceutical preparation is intended for transdermal delivery system preferably for cancer therapy either individually or the combination.

Advantages of the Invention:

  • It provides a multi-purpose wound healing matrix with a bandage for compromised tissues viz. skin having wounds or melanoma.
  • Enhanced bioavailability of its individual components, working together in a synergistic way.
  • Another promising advantage of this phytopharmaceutical invention is that it displays minimal side effects in clinical applications of the drug.
  • Since the components in the formulation are from herbal / natural resources, it is very safe and eco – friendly and does not produce any adverse effect on the skin.

Following are the broad range of applications:

  • Anti-microbial
  • Anti-inflammatory
  • Analgesic
  • Antioxidant
  • Wound healing
  • Radiation poisoning
  • Modulates immunity
  • Biocompatible
  • Haemostatic
  • Nano based technology for drug releasing
  • Anti-cancer properties
  • Multiple sclerosis

Follow us @Datt Mediproducts to know more about such innovative patented.

Visit www.dattmedi.com for more infomation.
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Recent Blogs
Wound Care in Diabetes

Diabetes significantly increases the risk of developing chronic wounds, particularly foot ulcers. Effective wound care is crucial for preventing complications and promoting healing in diabetic patients. In this blog, you will explore the nature of diabetic wounds, prevention techniques, and management strategies to help healthcare professionals and patients navigate these challenges.

Understanding Diabetic Wounds

Diabetic wounds, especially foot ulcers, are common complications resulting from prolonged high blood sugar levels. These wounds often develop due to neuropathy (nerve damage) and peripheral arterial disease, which impair sensation and blood flow. Consequently, minor injuries can go unnoticed and progress into serious ulcers. Left untreated, these ulcers can lead to severe infections and, in extreme cases, amputations.

1. Prevention Techniques for Diabetic Ulcers:

Preventing diabetic ulcers is essential to reduce the risk of severe complications. Here are some effective prevention strategies.

2. Regular Foot Inspections: 

Diabetic patients should inspect their feet (or have someone inspect it) on a daily basis for cuts, blisters, redness, or swelling. Early detection of potential issues can prevent minor problems from becoming serious ulcers.

3. Proper Footwear: 

  • Wearing well-fitting shoes and socks designed for diabetics can prevent pressure points and reduce the risk of injuries. 
  • Avoid wearing tight stockings or socks with elastic tops as they can reduce blood flow.
  • Avoid extreme hot or cold temperatures.
  • Do not treat corn or calluses on your own. 
  • Avoiding barefoot walking, even at home, is crucial.

4. Good Hygiene: 

Keeping feet clean and dry is essential. Patients should wash their feet daily with mild soap and water, then dry them thoroughly, especially between the toes.

5. Blood Sugar Control: 

Maintaining optimal blood sugar levels through diet, exercise, and medication can significantly reduce the risk of neuropathy and poor circulation, which contribute to ulcer formation.

6. Regular Medical Foot Check-Ups: 

Routine visits to a healthcare provider or a podiatrist for foot exams can help identify and address problems early.

7. Management Strategies for Diabetic Patients:

When ulcers do occur, effective management is vital to promote healing and prevent complications.

Here are some key strategies:

  • Wound Cleaning and Dressing: Keeping the ulcer clean and protected is essential. Cleaning the wound with a saline solution and using appropriate dressings, such as those provided by DMP Velvert®, can create an optimal healing environment. It provides a barrier to external contaminants, aids absorption of exudates and accelerates wound healing.
  • Debridement: Removing dead tissue from the wound (debridement) can accelerate the healing process. This procedure should be performed by a healthcare professional.
  • Pressure Offloading: Reducing pressure on the affected area is crucial. Patients may need special footwear, casts, or braces to alleviate pressure on the ulcer. Foot or mobility exercises also help in decreasing peak pressure, increasing foot and ankle range of motion and it improves neuropathy symptoms.
  • Infection Control: Monitoring for signs of infection and using antibiotics when necessary is critical. Proper wound care products, like Velvert®, which offer antimicrobial properties, can help prevent infections.
  • Blood Flow Improvement: Enhancing blood circulation through medical treatments or lifestyle changes can aid in the healing process. This might include medications, physical therapy, or surgical interventions. Revascularization results in increased tissue perfusion, which can further reduce amputation rates.
Diabetic ulcers are a serious complication of diabetes, but with proper prevention and management strategies, their impact can be significantly reduced. Regular foot inspections, good hygiene, appropriate footwear, and effective blood sugar control are key preventive measures. When ulcers do develop, it is best to catch them in the early stages when they are small, products combined with professional medical care, can promote healing and prevent complications.

At Datt Mediproducts, we offer Velvert®, an advanced wound care solution designed to aid in the management of diabetic ulcers. Velvert® dressings are crafted to provide superior moisture retention and protection, creating an optimal environment for wound healing. They also incorporate antimicrobial properties to reduce the risk of infection, which is crucial for diabetic patients. Velvert® is easy to apply and remove, ensuring minimal discomfort for patients.

Wound Care Myths Debunked

When it comes to wound care, there’s a lot of advice floating around. Some of it is helpful, while other bits are more myth than fact. Let’s clear up some common wound care myths and get to the truth behind them.

Myth 1: Wounds Need Sunlight to Heal

Fact: While sunshine is great for your mood, it’s not beneficial for healing wounds. In fact, direct sunlight can actually cause burns and damage the tissues that are trying to heal. So, to promote proper healing, keep wounds covered and out of direct sunlight.
Source : Cleveland Clinic

Myth 2: Wound Itching Means Healing

Fact: A bit of itching around a wound can be a sign that it’s healing, but it’s not always the case. Itching might also indicate an allergic reaction or infection. Monitor any itching along with other symptoms to ensure the healing process is on track.
Source : Advanced Tissue

Myth 3: Hydrogen Peroxide is the Best Cleaner for Wounds

Fact: Using hydrogen peroxide to clean wounds can actually slow down the healing process by damaging healthy cells. Instead, stick to gentle cleansing with mild soap and water to keep things clean without causing additional damage.
Source : University of Utah Healthcare & Atlantic Foot & Ankle Specialists

Myth 4: Keep Wounds Dry for Faster Healing

Fact: While it’s essential to keep wounds clean, keeping them too dry can actually slow down the healing process. Wounds heal better in a moist environment, so using dressings to maintain the right level of moisture can speed up recovery.
Source : LifeMD™

Understanding the Importance of Proper Wound Care

Wound care isn’t just about cleaning and covering a wound; it’s about understanding the underlying processes that help your body repair itself. Following evidence-based practices ensures that wounds heal properly and complications are minimized. Here’s why these practices are crucial:

  • Preventing Infections: Proper wound care minimizes the risk of infection, which can complicate healing and lead to more serious health issues.
  • Promoting Faster Healing: By maintaining a moist environment and protecting the wound, you accelerate the natural healing process.

When to Seek Professional Help

While minor cuts and scrapes can often be treated at home, certain situations warrant professional medical attention:

  • Deep or Large Wounds: Significant injuries that penetrate deep into the skin or are extensive in size require medical assessment.
  • Signs of Infection: Redness, swelling, increased pain, warmth around the wound, or pus are signs of infection that need medical intervention.
  • Delayed Healing: If a wound does not show signs of healing within a reasonable period, it’s important to consult a healthcare provider.

In a nutshell, taking care of wounds isn’t complicated, but it’s important to distinguish fact from fiction. By following evidence-based practices and seeking professional advice when needed, you can ensure your wounds heal properly and without unnecessary complications.

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