US Patent Granted For An Artificial Skin Substitute
US Patent Granted For An Artificial Skin Substitute

Patent No.1: US 10, 004, 830 B2
Date of the Patent Granted: Jun. 26, 2018
Patent No.3: US 10, 149, 924 B1
Date of the Patent Granted: Dec. 11, 2018
Patent No.2: US 10, 098, 986 B1
Date of the Patent Granted: Oct. 16, 2018
Title of the Patent: READY TO USE BIODEGRADABLE AND BIOCOMPATIBLE ARTIFICIAL SKIN SUBSTITUTE AND A METHOD OF PREPARATION THEREOF

NEED OF THE INVENTION:

Wound Healing is a complex biological process. The main goal of the treatments is to achieve wound closure. In the cases of large wounds like burns, the availability of skin covers to repair the damaged areas is a problem. Different treatment modalities are available depending upon the type of the wound and the physician’s approach.

These may include surgical closure (primary intention), wound left open to close by a reparative process (secondary intention) or wound left open because of infection and closed surgically later (tertiary intention).

Since the primary goal is wound closure, the quality of healing is important because in the cases of deeper wounds the chances of infection and scar formation are very high.

Mesenchymal stem cells are progenitor cells of mesoderm origin. These were initially isolated from bone marrow. However, at present these can be isolated from the number of tissue niches including dental pulp, adipose tissue, umbilical cord, umbilical cord blood, skin, skeletal muscle etc. These are multipotent, immune-privileged cells, which can differentiate into multiple lineages including skin cells.

Therefore, they have been very instrumental in the field of regenerative medicine. Skin is the largest organ of the body and harbors stem cells within it which helps in repair. However, in the case of chronic wounds, the normal repair process gets delayed and it takes the very long time to heal.

This can be the result of various disorders like diabetic foot ulcer, severe burns, vasculitis etc. Chronic wounds cause substantial patient morbidity, with detrimental effects on patient quality of life, increasing pain, stress, depression, and social isolation.

Normal wound healing occurs in 3 stages:
1) Inflammation
2) Proliferation
3) Remodeling.

We @ Datt Mediproducts have developed a stem cell-based extracellular matrix for the treatment of burns, diabetic foot ulcer, and other chronic wounds. This matrix has tissue-like properties and can be used for wound healing. This patent describes the invention as well as the in-vitro method of cell-based skin substitute preparation.

ABOUT THE INVENTION:

The present invention provides a novel and unique technique of culturing of proliferating human mesenchymal stem cells on a biocompatible matrix membrane to form a confluent layer of cell sheet with secreted growth factors, suitable for grafting. This invention also provides a ready to use biodegradable and biocompatible tissue construct with autologous/allogeneic human stem cell-based product.

The innovative product has tissue-like properties and is a very effective, easy to use, cost-effective artificial skin substitute. The present invention uses proliferative/confluent Mesenchymal stem cells (MSCs), fibroblast, keratinocytes, and Mesenchymal stem cells differentiated fibroblast and keratinocytes whereby cells are transferred from culture to the wound bed.

This product not only helps to achieve satisfactory wound closure but also helps to restore functional integrity in the least time and with the least complications and morbidity.

Advantages of the Invention:
– Provides the support, growth factors and essential cytokines for wound healing.
– The scaffold of the present invention does not stick to the wound.
– The present invention comprises of improved wound and hygiene.
– It can be manufactured in any size and shape as per the requirement.
– Easy to handle.
– It can be removed easily.
– Environment friendly as it is degradable easily.
– It aids in wound healing.
– It ensures rapid healing of wound.
– It ensures moist wound environment by preventing wound desiccation.

The graft can be made within 15 days. It is an alternative treatment to the standard wound management therapies. There is a dramatically reduced risk of transmission of infectious disease due to rigorous process controls.

INTENDED USE:

Grafting to a patient with tissue or organ defect, such as skin ulcer or wound, or in vitro tissue testing or animal graftings such as for safety testing or validation of pharmaceutical, cosmetic, and chemical products.

Follow us @ Datt Mediproducts to know more about the company and product.

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Specific Considerations for Different Wounds

When it comes to wound care, one size does not fit all. Each wound has its own unique characteristics and possible complications. Tailoring first aid steps to specific types of injuries can significantly impact healing outcomes and minimize complications.

In this blog post, we look at different wounds with specific considerations emphasising the need for individualised care and additional precautions to enhance better results.

Understanding Different Wounds:

1. Burns:

First-degree burns: These affect only the outer layer of skin, causing redness and mild pain. Immediate first aid involves cooling the burn with cold water or a clean, damp cloth and then applying aloe vera gel. Cover the burn area with a sterile non stick bandage, this will help protect the damaged area from contaminants and the sun. 

Second-degree burns: These penetrate deeper into the skin, going through the first and second layer of the skin, causing blistering and severe pain. First aid includes cooling the burn, covering it loosely with a sterile gauze bandage, and seeking medical attention.

Third-degree burns: These are the most severe, affecting all layers of the skin and potentially deeper tissues. Third degree burns should always be treated by a healthcare provider and never at home. First aid involves not removing any clothing stuck to the burn, covering it with a clean, dry cloth, and seeking emergency medical help immediately.

2. Deep Cuts:

2a. Apply pressure: Use a sterile gauze pad or clean cloth to apply firm pressure to stop bleeding.
2b. Clean the wound: Once the bleeding has stopped rinse the cut with clean water to remove any debris and dirt.
2c. Bandage the wound: Once it has been cleaned properly, cover the cut with a sterile bandage or gauze pad and secure it with medical tape.
2d. Seek medical attention: Deep cuts may require stitches to promote proper healing and reduce the risk of infection.

3. Abrasions:
Abrasions, also known as scrapes, occur when the skin is rubbed or scraped against a rough surface, causing superficial damage.

3a. First aid involves cleaning the abrasion with soap and water to remove debris and applying an antibiotic ointment to prevent infection.
3b. Cover the abrasion with a sterile bandage or gauze pad to protect it from further irritation and promote healing.
3c. Change the dressing on a regular basis and check the area daily
3d. If there are any signs of an infection such as, fever, swelling, an increase in redness or fluid seek medical help from a healthcare provider.

4. Puncture Wounds: 
Puncture wounds are caused by sharp objects piercing the skin, such as nails, needles, or animal bites. Such types of wounds have a greater risk of infection as bacteria are being pushed into the skin.

4a. First aid involves cleaning the wound thoroughly with soap and water to remove any dirt or debris.
4b. Do not attempt to remove any object embedded in the skin. Instead, stabilize the object and seek medical attention immediately.
4c. Cover the puncture wound with a clean cloth or sterile bandage to reduce the risk of infection until medical help arrives.

Therefore, understanding the characteristics and appropriate first aid measures for different types of wounds is essential for providing effective care and promoting optimal healing outcomes.

Tailored First Aid:

Children:
a. Children’s skin is more delicate and prone to infection. Use extra caution when cleaning and bandaging wounds.
b. Consider using adhesive bandages with fun designs to make the first aid process less intimidating for children.

Elderly:
a. Elderly individuals may have thinner skin and reduced circulation, making them more susceptible to skin tears and slow wound healing.
b. Be gentle when cleaning and bandaging wounds to avoid causing further damage.

Individuals with Diabetes:
a. Diabetes can impair blood flow and reduce sensation in the extremities, increasing the risk of foot ulcers and slow-healing wounds.
b. Inspect feet daily for any signs of injury and seek prompt medical attention for any cuts or sores.

Precautions and Practices – 
In addition to first aid measures designed for specific wound types, there are several precautions and practices to keep in mind:

1. Always wash your hands thoroughly before and after your first treatment to prevent the spread of infection.
2. Use disposable gloves when treating the wound to reduce the risk of contamination.
3. Avoid using alcohol or hydrogen peroxide directly on the wound, as it can damage healthy tissue.
4. Keep first aid kits safe and easily accessible in an emergency.

Tailoring first aid measures to specific types of wounds is crucial for effective treatment and optimal healing. Whether it’s a minor burn or a deep cut, understanding the unique needs of each injury and taking appropriate action can make a significant difference in recovery outcomes and help in reducing the risk of complications.

For more information on our comprehensive range of wound care products, including Antimicrobial Dressings, Compression Bandages, and Film & post-operative Dressings, Visit www.dattmedi.com for more information.

In moments of crisis, such as accidents or emergencies, being equipped with the knowledge and skills to administer proper wound care can make a critical difference in saving lives and preventing further complications.

Whether you’re a bystander or the injured person themselves, understanding the essential steps of wound care in emergency situations is paramount. 

Here are some quick response tips to guide you through assessing and managing wounds effectively:

Assessment and Safety First:
The foremost priority in any emergency situation is safety. Before rushing to aid the injured person, take a moment to assess the surroundings for potential hazards. Ensure both your safety and that of the injured individual by identifying and eliminating any immediate dangers.

Control Bleeding:
One of the most crucial steps in wound care is controlling bleeding. Apply direct pressure to the wound using a clean cloth or dressing. Elevating the injured area, if feasible, can help reduce blood flow and minimize bleeding. Prompt action in staunching the blood flow can prevent further loss and stabilize the individual’s condition.

Clean the Wound Quickly:
After addressing the bleeding, it’s essential to clean the wound promptly. Rinse the wound gently with clean water to remove any debris or foreign objects. In emergency situations, it’s advisable to avoid using strong antiseptics or solutions unless absolutely necessary, as they can cause further irritation or delay in treatment.

Apply Dressing and Bandage:
Once the wound is cleaned, cover it with a sterile dressing or a clean cloth to protect it from contamination. Secure the dressing in place using a bandage or cloth, ensuring it is snug but not too tight to impede circulation. Proper dressings help create an optimal environment for wound healing while preventing infection.

Seek Medical Assistance:
While initial wound care is essential, it’s crucial to recognize the severity of the injury and seek professional medical assistance promptly. Call emergency services or transport the individual to the nearest medical facility if the wound is severe, deep, or if bleeding persists despite initial measures. Timely medical intervention can prevent complications and facilitate proper wound management.

Prevent Shock and Comfort the Injured:
In addition to physical care, it’s vital to address the emotional and psychological needs of the injured person. Keep them calm and reassured to prevent shock, covering them with a blanket to maintain body warmth and comfort. Offering words of encouragement and support can go a long way in alleviating distress.

Continued Monitoring and Updates:
Even after administering initial first aid, it’s essential to continue monitoring the injured person’s condition until professional help arrives. Stay vigilant for any signs of deterioration or changes in vital signs, providing updates and relevant information to emergency responders upon their arrival. Your ongoing support and assistance can contribute significantly to the individual’s overall well-being and recovery.

Therefore, effective wound care in emergency situations requires a combination of swift action, sound judgment, and compassion. By prioritizing safety, controlling bleeding, cleaning the wound, seeking medical assistance, providing comfort, and monitoring the individual’s condition, you can help ensure the best possible outcome for the injured person. Remember, every second counts in an emergency, and your actions can make a lifesaving difference.

For more information on our comprehensive range of wound care products, including Antimicrobial Dressings, Compression Bandages, and Film & post-operative Dressings, Visit www.dattmedi.com for more information.

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