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US Patent Granted For An Artificial Skin Substitute

Patent No.1: US 10, 004, 830 B2
Date of the Patent Granted: Jun. 26, 2018
Patent No.3: US 10, 149, 924 B1
Date of the Patent Granted: Dec. 11, 2018
Patent No.2: US 10, 098, 986 B1
Date of the Patent Granted: Oct. 16, 2018
Title of the Patent: READY TO USE BIODEGRADABLE AND BIOCOMPATIBLE ARTIFICIAL SKIN SUBSTITUTE AND A METHOD OF PREPARATION THEREOF

NEED OF THE INVENTION:

Wound Healing is a complex biological process. The main goal of the treatments is to achieve wound closure. In the cases of large wounds like burns, the availability of skin covers to repair the damaged areas is a problem. Different treatment modalities are available depending upon the type of the wound and the physician’s approach.

These may include surgical closure (primary intention), wound left open to close by a reparative process (secondary intention) or wound left open because of infection and closed surgically later (tertiary intention).

Since the primary goal is wound closure, the quality of healing is important because in the cases of deeper wounds the chances of infection and scar formation are very high.

Mesenchymal stem cells are progenitor cells of mesoderm origin. These were initially isolated from bone marrow. However, at present these can be isolated from the number of tissue niches including dental pulp, adipose tissue, umbilical cord, umbilical cord blood, skin, skeletal muscle etc. These are multipotent, immune-privileged cells, which can differentiate into multiple lineages including skin cells.

Therefore, they have been very instrumental in the field of regenerative medicine. Skin is the largest organ of the body and harbors stem cells within it which helps in repair. However, in the case of chronic wounds, the normal repair process gets delayed and it takes the very long time to heal.

This can be the result of various disorders like diabetic foot ulcer, severe burns, vasculitis etc. Chronic wounds cause substantial patient morbidity, with detrimental effects on patient quality of life, increasing pain, stress, depression, and social isolation.

Normal wound healing occurs in 3 stages:
1) Inflammation
2) Proliferation
3) Remodeling.

We @ Datt Mediproducts have developed a stem cell-based extracellular matrix for the treatment of burns, diabetic foot ulcer, and other chronic wounds. This matrix has tissue-like properties and can be used for wound healing. This patent describes the invention as well as the in-vitro method of cell-based skin substitute preparation.

ABOUT THE INVENTION:

The present invention provides a novel and unique technique of culturing of proliferating human mesenchymal stem cells on a biocompatible matrix membrane to form a confluent layer of cell sheet with secreted growth factors, suitable for grafting. This invention also provides a ready to use biodegradable and biocompatible tissue construct with autologous/allogeneic human stem cell-based product.

The innovative product has tissue-like properties and is a very effective, easy to use, cost-effective artificial skin substitute. The present invention uses proliferative/confluent Mesenchymal stem cells (MSCs), fibroblast, keratinocytes, and Mesenchymal stem cells differentiated fibroblast and keratinocytes whereby cells are transferred from culture to the wound bed.

This product not only helps to achieve satisfactory wound closure but also helps to restore functional integrity in the least time and with the least complications and morbidity.

Advantages of the Invention:
– Provides the support, growth factors and essential cytokines for wound healing.
– The scaffold of the present invention does not stick to the wound.
– The present invention comprises of improved wound and hygiene.
– It can be manufactured in any size and shape as per the requirement.
– Easy to handle.
– It can be removed easily.
– Environment friendly as it is degradable easily.
– It aids in wound healing.
– It ensures rapid healing of wound.
– It ensures moist wound environment by preventing wound desiccation.

The graft can be made within 15 days. It is an alternative treatment to the standard wound management therapies. There is a dramatically reduced risk of transmission of infectious disease due to rigorous process controls.

INTENDED USE:

Grafting to a patient with tissue or organ defect, such as skin ulcer or wound, or in vitro tissue testing or animal graftings such as for safety testing or validation of pharmaceutical, cosmetic, and chemical products.

Follow us @ Datt Mediproducts to know more about the company and product.

Visit www.dattmedi.com for more info
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Managing Orthopedic Injuries

Sports seasons bring excitement and competition, but they also increase the risk of orthopedic injuries. Athletes must adopt preventive measures and utilize effective injury management strategies to ensure peak performance and long-term health.

This guide explores common injuries, prevention strategies, and the role of orthopedic products in recovery.

Common Orthopedic Injuries in Athletes

Athletes often face various orthopedic injuries, including:

1. Sprains, Strains, and Fractures

Sprains: A sprain occurs when ligaments (the tissue connecting bones) are stretched or torn, often caused by sudden twisting or rolling of a joint.
Example: A soccer player might twist their ankle while changing direction quickly on the field, resulting in an ankle sprain.

Strains: A strain is an injury to muscles or tendons caused by overuse, overstretching, or excessive force.
Example: A weightlifter lifting a heavy load with improper form might experience a strain in their lower back muscles.

Fractures: A fracture refers to a break in a bone, which can occur due to high-impact collisions or falls.Example: A cyclist who crashes and lands on their arm might suffer a wrist fracture.

2. Tendon Injuries

Tendons are the fibrous tissues connecting muscles to bones, and they can become inflamed or torn due to overuse or repetitive movements.
Example: A tennis player might develop tennis elbow, a condition caused by repetitive strain on the tendons of the forearm. Similarly, a runner could experience Achilles tendonitis from frequent uphill running or poor footwear.

3. Overuse Injuries

Overuse injuries result from repetitive stress on bones, muscles, or joints without adequate rest or recovery time.

Stress Fractures: Tiny cracks in bones caused by repetitive impact activities like running or jumping.
Example: A marathon runner who increases mileage too quickly might develop a stress fracture in their foot.

Shin Splints: Pain along the shin bone caused by overuse of lower leg muscles.
Example: A basketball player who practices on hard courts for extended periods might develop shin splints due to the repetitive impact.

Prevention Strategies for Athletes

Preventing injuries requires a proactive approach that combines preparation, proper equipment, and targeted training:

1. Warm-Up and Cool-Down Routines:
Dynamic stretching and gradually increasing activity levels prepare muscles for exertion, improving flexibility and blood flow. Post-activity stretching helps reduce muscle stiffness and aids in recovery.

2. Proper Gear:
Using well-fitted shoes and sport-specific protective equipment minimizes the risk of injuries caused by poor support or inadequate protection.

3. Strength and Flexibility Training:
Incorporating targeted exercises strengthens muscles, enhances joint stability, and improves range of motion, reducing the likelihood of injury.
Example: A sprinter who performs a comprehensive warm-up involving dynamic stretches (such as leg swings and high knees) and wears track-specific, cushioned running shoes is less likely to experience a hamstring strain compared to an athlete who skips these steps and runs in ill-fitted or non-specialized shoes.

Innovative Orthopedic Solutions:

Orthopedic products such as Cokomp™ Compression Bandage, Velsoft® Adhesive Bandage, and Velfour®-Plus are designed to provide tailored support and recovery solutions. From managing swelling with targeted compression to providing flexible and lightweight joint support, these products address a variety of athletic needs effectively.

When to Seek Professional Help

Certain signs indicate the need for medical attention to prevent further complications:

– Severe swelling or bruising that doesn’t subside.
– Inability to bear weight on the affected limb.
– Persistent pain or visible deformities.

Physical therapy often plays a key role in recovery, helping athletes regain strength and mobility post-injury.

Building a Safe Sports Culture

Fostering a safe sports environment involves education and awareness:

Educating Athletes: Emphasize the importance of injury prevention, recognizing symptoms, and administering first aid.

Role of Coaches and Trainers: Encourage proper technique, regular rest, and adherence to safety protocols to minimize injury risks.

Fostering a safe sports environment requires a holistic strategy that emphasizes education, preparation, and recovery. By integrating preventive measures, timely intervention, and the right orthopedic solutions, athletes can minimize the impact of injuries while optimizing performance.

Our advanced orthopedic solutions provide tailored support and comfort, helping athletes recover faster and maintain mobility. Whether it’s targeted compression or flexible support, our products are designed with athletes’ unique needs in mind.

Equip yourself for a safer, healthier sports season with Datt Mediproducts. Our innovative range of orthopedic solutions, including high-quality compression bandages and supportive products, is designed to meet the unique needs of athletes. Discover how our products can enhance recovery and performance at Datt Mediproducts.

Managing Chronic Wounds

Chronic wounds, such as diabetic foot ulcers and pressure sores, pose a significant challenge to healthcare providers due to their resistance to healing. Factors such as poor circulation, diabetes, and malnutrition contribute to the delayed tissue regeneration seen in these wounds. This guide explores strategies to improve outcomes for diabetic patients dealing with chronic wounds.

Understanding Chronic Wounds

Chronic wounds develop and persist due to underlying systemic issues that impede natural healing. These include:

1. Diabetic Foot Ulcers: Resulting from reduced blood flow and nerve damage, often on the feet.
2. Pressure Sores (Bedsores): Caused by prolonged pressure on the skin, commonly in bedridden patients.
3. Venous Leg Ulcers: Linked to chronic venous insufficiency, where blood flow back to the heart is impaired.

For example, a diabetic foot ulcer might remain unhealed due to compromised blood circulation and nerve damage, requiring a tailored approach compared to pressure sores caused by external forces.

Selecting the Right Dressing

The choice of wound dressing plays a pivotal role in effective management:

1. Hydrocolloid Dressings: Ideal for moderately exuding wounds; they absorb moisture, maintain a moist healing environment, and prevent infections. This makes them particularly effective for diabetic foot ulcers.

2. Hydrogels: Suitable for dry wounds as they provide moisture to the wound bed, encouraging healing. However, they may not prevent infection and should be used in conjunction with appropriate infection control measures.

Infection Control: The Role of Antimicrobial Dressings
Chronic wounds are prone to infections that can hinder the healing process. Antimicrobial dressings play a crucial role in managing these infections and promoting recovery.

Introducing Velvert®, a natural-based patented antimicrobial formulation designed to address infection control in chronic wounds. Velvert® is broad-spectrum in nature, effectively combating all major superbugs and accelerating the wound healing process. Its advanced formulation is highly biocompatible, ensuring no side effects or contraindications, making it a safe and reliable choice for patients.

Example: A pressure ulcer with a high risk of bacterial colonization benefits greatly from using Velvert®. Its broad-spectrum action not only reduces bacterial load but also creates an optimal healing environment, leading to faster recovery and improved patient outcomes.

Managing Exudate Levels

Excess moisture or dryness can impede wound healing. Dressing selection must align with the wound’s exudate level:

1. Foam Dressings: Effective for heavily exuding wounds due to their superior absorption capabilities.

2. Hydrocolloid Dressings: Suitable for wounds with moderate exudate, maintaining moisture balance without risking maceration.

Foam vs. Hydrocolloid for Heavy Exudate

Foam dressings are the preferred choice for high-exudate wounds as they prevent saturation and maceration. Hydrocolloid dressings may become overwhelmed, compromising the wound’s healing environment.

Nutritional and Lifestyle Interventions

Healing chronic wounds requires addressing systemic factors, including nutrition and blood glucose management:

1. Nutrition: Adequate intake of vitamins A, C, zinc, and protein supports tissue regeneration and immune function.

2. Glucose Control: Poor glucose control in diabetic patients delays healing. Maintaining optimal levels is essential for recovery.

For instance, a diabetic patient consuming a nutrient-rich diet while effectively managing their glucose levels is more likely to experience faster wound healing.

Continuous Monitoring and Expert Care

Regular assessment by healthcare professionals is essential for chronic wound management. Adjustments to treatment plans based on wound progress ensure the best outcomes. Starting with antimicrobial dressings often sets the foundation for successful healing without the need to switch to standard dressings.

Chronic wounds in diabetic patients demand a multifaceted approach that includes selecting the right dressings, managing infections and exudate, and addressing systemic factors such as nutrition and glucose control. By following these best practices, healthcare providers can significantly improve healing outcomes, reduce complications, and enhance the quality of life for patients.

At Datt Mediproducts, we are committed to delivering next-generation wound care solutions that prioritize patient comfort and clinical efficacy. Our range of advanced dressings, including gauze-based, film, post-operative, and antimicrobial options, is designed to cater to diverse wound management needs. Explore our comprehensive portfolio and discover how we can support your wound care journey. Visit www.dattmedi.com/wound-care.html to learn more.

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