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US Patent Granted For An Artificial Skin Substitute

Patent No.1: US 10, 004, 830 B2
Date of the Patent Granted: Jun. 26, 2018
Patent No.3: US 10, 149, 924 B1
Date of the Patent Granted: Dec. 11, 2018
Patent No.2: US 10, 098, 986 B1
Date of the Patent Granted: Oct. 16, 2018
Title of the Patent: READY TO USE BIODEGRADABLE AND BIOCOMPATIBLE ARTIFICIAL SKIN SUBSTITUTE AND A METHOD OF PREPARATION THEREOF

NEED OF THE INVENTION:

Wound Healing is a complex biological process. The main goal of the treatments is to achieve wound closure. In the cases of large wounds like burns, the availability of skin covers to repair the damaged areas is a problem. Different treatment modalities are available depending upon the type of the wound and the physician’s approach.

These may include surgical closure (primary intention), wound left open to close by a reparative process (secondary intention) or wound left open because of infection and closed surgically later (tertiary intention).

Since the primary goal is wound closure, the quality of healing is important because in the cases of deeper wounds the chances of infection and scar formation are very high.

Mesenchymal stem cells are progenitor cells of mesoderm origin. These were initially isolated from bone marrow. However, at present these can be isolated from the number of tissue niches including dental pulp, adipose tissue, umbilical cord, umbilical cord blood, skin, skeletal muscle etc. These are multipotent, immune-privileged cells, which can differentiate into multiple lineages including skin cells.

Therefore, they have been very instrumental in the field of regenerative medicine. Skin is the largest organ of the body and harbors stem cells within it which helps in repair. However, in the case of chronic wounds, the normal repair process gets delayed and it takes the very long time to heal.

This can be the result of various disorders like diabetic foot ulcer, severe burns, vasculitis etc. Chronic wounds cause substantial patient morbidity, with detrimental effects on patient quality of life, increasing pain, stress, depression, and social isolation.

Normal wound healing occurs in 3 stages:
1) Inflammation
2) Proliferation
3) Remodeling.

We @ Datt Mediproducts have developed a stem cell-based extracellular matrix for the treatment of burns, diabetic foot ulcer, and other chronic wounds. This matrix has tissue-like properties and can be used for wound healing. This patent describes the invention as well as the in-vitro method of cell-based skin substitute preparation.

ABOUT THE INVENTION:

The present invention provides a novel and unique technique of culturing of proliferating human mesenchymal stem cells on a biocompatible matrix membrane to form a confluent layer of cell sheet with secreted growth factors, suitable for grafting. This invention also provides a ready to use biodegradable and biocompatible tissue construct with autologous/allogeneic human stem cell-based product.

The innovative product has tissue-like properties and is a very effective, easy to use, cost-effective artificial skin substitute. The present invention uses proliferative/confluent Mesenchymal stem cells (MSCs), fibroblast, keratinocytes, and Mesenchymal stem cells differentiated fibroblast and keratinocytes whereby cells are transferred from culture to the wound bed.

This product not only helps to achieve satisfactory wound closure but also helps to restore functional integrity in the least time and with the least complications and morbidity.

Advantages of the Invention:
– Provides the support, growth factors and essential cytokines for wound healing.
– The scaffold of the present invention does not stick to the wound.
– The present invention comprises of improved wound and hygiene.
– It can be manufactured in any size and shape as per the requirement.
– Easy to handle.
– It can be removed easily.
– Environment friendly as it is degradable easily.
– It aids in wound healing.
– It ensures rapid healing of wound.
– It ensures moist wound environment by preventing wound desiccation.

The graft can be made within 15 days. It is an alternative treatment to the standard wound management therapies. There is a dramatically reduced risk of transmission of infectious disease due to rigorous process controls.

INTENDED USE:

Grafting to a patient with tissue or organ defect, such as skin ulcer or wound, or in vitro tissue testing or animal graftings such as for safety testing or validation of pharmaceutical, cosmetic, and chemical products.

Follow us @ Datt Mediproducts to know more about the company and product.

Visit www.dattmedi.com for more infomation.
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In the realm of healthcare, attention to detail is paramount, especially when it comes to catering to the needs of sensitive patients. One often overlooked aspect is the choice of medical tapes for securing dressings, tubes, and medical devices.

For individuals with delicate or sensitive skin, such as pediatric patients, the elderly, and those with skin conditions, the selection of appropriate tapes can make a significant difference in their comfort and recovery process. This blog will cover the importance of skin-friendly tapes like Minipore™, Velpore™, and Velsilk™ in enhancing patient care and promoting healing.

Understanding the Sensitivity

Sensitive skin can be a result of various factors, such as age, skin conditions, or prolonged exposure to medical treatments. Patients undergoing chemotherapy, individuals with dermatitis, or those with compromised immune systems require extra care to prevent skin damage. Traditional medical tapes, while effective in securing medical devices, can sometimes cause irritation, allergic reactions, or damage to fragile skin. This is precisely where the importance of skin-friendly tapes becomes conspicuous

Introducing Minipore™, Velpore™, and Velsilk™ Tapes

Minipore™, Velpore™, and Velsilk™ are revolutionary medical tapes designed to address the unique needs of sensitive patients. These tapes stand out for their skin-friendly properties and their contribution to patient comfort.

Minipore™:

Minipore™ tape is a hypoallergenic paper tape that offers gentle adhesion, making it suitable for patients with sensitive or fragile skin. It allows for breathability, reducing the risk of skin maceration while securely holding dressings in place.
Read more about products visit https://dattmedi.com/minipore.html

Velpore™:

Velpore™ surgical paper tape possesses hypoallergenic qualities, making it ideal for individuals with sensitive skin or allergies. Its gentle nature ensures it is kind to the skin. The microporous structure of Velpore enables exceptional breathability, facilitating airflow and minimizing the likelihood of maceration.This tape is frequently utilized for securing wound dressings, delivering dependable fixation while enabling freedom of movement and flexibility. Its mild adhesive properties allow for painless and damage-free removal from the skin.
Read more about products visit https://www.dattmedi.com/velpore.html

Velsilk™:

Velsilk™ tape is a silk-like cloth tape that combines excellent adhesion with gentle removal. It adheres securely to the skin while minimizing discomfort during tape removal. It is particularly useful in situations where frequent dressing changes are required, as it allows for easy application and removal.
Read more about products visit https://www.dattmedi.com/velsilk.html

Advantages of Skin-Friendly Tapes

The importance of using skin-friendly tapes like Minipore™, Velpore™, and Velsilk™ cannot be overstated. Here are some key advantages they offer:

  • Reduced Skin Irritation: The hypoallergenic adhesive and soft materials minimize the risk of skin irritation or allergic reactions, promoting patient comfort during the healing process.
  • Enhanced Healing: Breathable materials enable proper air circulation around wounds, supporting the body’s natural healing mechanisms.
  • Painless Removal: The gentle adhesive used in these tapes ensures painless removal, reducing the potential for skin trauma.
  • Versatility: Skin-friendly tapes are versatile in their applications, suitable for various medical scenarios, from wound dressings to tubing fixation.
  • Patient Confidence: Patients experience enhanced comfort and security, which can have a positive impact on their overall well-being and recovery.

When it comes to healthcare, the focus should always be on patient well-being and comfort. The use of skin-friendly tapes like Minipore™, Velpore™, and Velsilk™ exemplifies this commitment. These tapes not only provide reliable adhesion for medical devices but also prioritize patient comfort and skin health

Childhood is a critical phase of development that lays the foundation for a healthy and fulfilling life. As parents, caregivers, and members of society, ensuring the health and well-being of our children is a top priority.

The early years of a child’s life are crucial for their development, setting the stage for their future health and happiness. By understanding the various aspects that contribute to a child’s overall well-being, we can create a solid foundation for their growth and help them thrive. In this blog, we will explore various aspects that contribute to building healthy foundations for children, including early childhood development, nutrition, physical activity, preventive healthcare, mental and emotional health, safe environments, and healthy sleep habits.

Understanding Early Childhood Development:

Early childhood development encompasses the physical, cognitive, social, and emotional growth that occurs from birth to around the age of eight. This period is crucial for brain development, language acquisition, and the formation of social skills. It is essential for parents and caregivers to engage children in stimulating activities, such as reading, playing, and problem-solving, to promote optimal development.

The Power of Nutrition:

Nutrition plays a vital role in a child’s growth and development. Providing a well-balanced diet that includes a variety of fruits, vegetables, whole grains, lean proteins, and dairy products is crucial. Adequate nutrition ensures that children receive the essential nutrients their bodies need to support physical growth, cognitive function, and immune system strength. Limiting sugary snacks and beverages can help prevent the development of unhealthy eating habits and reduce the risk of childhood obesity.

Promoting Physical Activity:

Regular physical activity is crucial for children’s overall health and well-being. It helps build strong bones and muscles, improves cardiovascular fitness, enhances coordination and motor skills, and contributes to a healthy weight. Encourage children to engage in age-appropriate activities such as active play, sports, and outdoor adventures. Limit screen time and promote active hobbies to ensure they maintain an active lifestyle.

Preventive Healthcare and Immunizations:

Preventive healthcare and immunizations are critical to safeguarding children’s health. Regular visits to healthcare providers for well-child check-ups allow for early detection and intervention of potential health concerns. Immunizations protect children from vaccine-preventable diseases, reducing their susceptibility to illnesses and safeguarding the health of the entire community. Staying up-to-date with recommended vaccinations ensures that children have a strong defense against infectious diseases.

Nurturing Mental and Emotional Health:

Promoting mental and emotional well-being is equally important for a child’s overall health. Creating a supportive and nurturing environment at home, school, and within the community helps children develop resilience, self-esteem, and positive coping skills. Encouraging open communication, active listening, and providing emotional support can assist children in navigating their emotions and building healthy relationships. Engaging in activities that promote creativity, self-expression, and mindfulness can also enhance their emotional well-being.

Safe Environments and Injury Prevention:

Creating a safe environment is essential for child health and well-being. Childproof your home by securing cabinets, electrical outlets, and sharp objects. Ensure a safe outdoor play area, free from hazards. Teach children about potential dangers, such as fire, water, and strangers, and how to stay safe in different situations. Supervision and education are crucial in preventing injuries.

Healthy Sleep Habits:

Adequate sleep is vital for children’s physical and cognitive development. Establish a consistent sleep routine and ensure children get the recommended amount of sleep based on their age. Create a calm and comfortable sleep environment, free from distractions. Limit screen time before bedtime, as it can interfere with quality sleep. Encourage relaxation techniques, such as reading or listening to soothing music, to promote better sleep.

Building healthy foundations for children requires a holistic approach that encompasses various aspects of their well-being. By understanding early childhood development, promoting proper nutrition, encouraging physical activity, prioritizing preventive healthcare, nurturing mental and emotional health, ensuring safe environments, and establishing healthy sleep habits, we can set children on a path towards a healthy and fulfilling life.

Together, let us prioritize their health, provide them with the support they need, and empower them to grow into happy, healthy individuals who can thrive and make a positive impact on the world. Let us join hands in creating a healthier future for our children.

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