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US Patent Granted for a Novel Herbal Dressing

Patent No.: US 10, 076, 552 B2
Date of the Patent Granted: Sep. 18, 2018
Title of the Patent: MULTIFUNCTIONAL FORMULATION COMPRISED OF NATURAL INGREDIENTS AND METHOD OF PREPARATION MANUFACTURING THEREOF

What is Wound Healing & need of the Invention:
Wound Healing is a complex process in which the injured tissue is repaired & regenerated and new tissues are formed. The whole process involves three different phases: inflammation, proliferative and remodeling. Each of these phases is controlled and regulated by biologically active substances called growth factors.

These growth factors are hormone-like molecules that interact with specific cell surface receptors to control the process of tissue repair. The research shows that re-epithelialization is enhanced by the presence of occlusive wound dressings which maintain a moisture barrier.

There are different treatment modalities available for the treatment of wounds and ulcers ranging from antibiotics, occlusive layers, bandages, poultices, mechanical devices that reduce evaporation of water and many others.

The major drawback of these treatment methods is that they enhance wound healing by supporting the body mechanisms to heal the wound. If the patient will have compromised immunity or other body functions that may not work optimally, wound healing will not take place or will be delayed. This may limit the mobility of the patient and lower the quality of life.

There is a need of the treatment method which could actively regenerate the skin, dermis and epidermis. We @ Datt Mediproducts have developed an innovative herbal based antimicrobial dressing which reduce the microflora in wounds and actively promotes healing by stimulating stem cells that are present even in deep wounds and enhance the migration of fibroblast and keratinocytes and secretion of growth factors.

ABOUT THE INVENTION:
The invention involves polymer chemistry and herbal formulation preparation for the treatment of compromised tissues like infected wounds, burn wounds and ulcers in both humans and animals. It is used as a topical device for a range of indications including anti – cancer transdermal patch for melanoma therapy, superbugs infected tropical wounds and multiple sclerosis also.

The invention is composed of a water solubilized nano-sized formulation of a non-aqueous extract of phyto-pharmaceuticals, animal or synthetic biocompatible gel or on matrix coated or both.

SUMMARY OF THE INVENTION:
The present invention provides a wound healing matrix comprising of a variety of natural ingredients, all working together in a synergistic way to promote wound healing by stimulating the stem cells. Stem cells have a great potential of cell division and are ultimately responsible for the homeostasis of steady state tissues.

Stem cells are normally slow cycling. However, there proliferation can be stimulated by certain growth factors. For example, cytokines such as Tumor Necrosis Factor (TNF), Epidermal Growth Factor (EGF), Transforming Growth Factor (TGF) and Interleukin-1 (IL-1) are believed to be useful.

The present invention consists of different herbs and synthetic biopolymers which are helpful in relieving pain, providing a soothing effect, and healing the wounds upon repeated use by providing a moist healing environment and stimulating the stem cells to regenerate the lost tissues.

The transdermal patch formulated with phytopharmaceutical preparation is intended for transdermal delivery system preferably for cancer therapy either individually or the combination.

Advantages of the Invention:

It provides a multi-purpose wound healing matrix with a bandage for compromised tissues viz. skin having wounds or melanoma.
Enhanced bioavailability of its individual components, working together in a synergistic way.
Another promising advantage of this phytopharmaceutical invention is that it displays minimal side effects in clinical applications of the drug.
Since the components in the formulation are from herbal / natural resources, it is very safe and eco – friendly and does not produce any adverse effect on the skin.

Following are the broad range of applications:

Anti-microbial
Anti-inflammatory
Analgesic
Antioxidant
Wound healing
Radiation poisoning
Modulates immunity
Biocompatible
Haemostatic
Nano based technology for drug releasing
Anti-cancer properties
Multiple sclerosis

Follow us @Datt Mediproducts to know more about such innovative patented.

Visit www.dattmedi.com for more infomation.

Wounds are a common part of life, whether from minor cuts, surgical procedures, or injuries. While most heal on their own with proper care, some wounds can develop complications that require medical attention.

Ignoring early warning signs can lead to infections or even severe health risks. Knowing when to seek medical help can make all the difference in ensuring a safe and speedy recovery.

Here are five key signs that indicate your wound might need professional care:

1. Increased Redness Around the Wound

A slight redness around a wound is normal, especially in the first few days. However, if you notice the redness spreading outward or deepening in color, it could be a sign of infection. This may indicate your immune system is fighting off bacteria, and medical treatment might be necessary.

When to worry: If the redness continues to expand or is accompanied by pain, swelling, or warmth, it’s time to consult a doctor.

2. Swelling or Warmth Around the Wound

Swelling is a natural response to injury; involving increased blood flow, the body’s immune response acting as a buffer to protect the injured area. But swelling should be continually decreasing, excessive swelling or warmth around the wound could mean trouble. These signs often indicate that your body is responding to an infection.

What to look for: If the wound becomes significantly puffy, feels hot to the touch, or the swelling doesn’t subside within a few days, it’s best to seek medical advice.

3. Pus or Unusual Discharge

One of the clearest signs of infection is pus — a thick, yellow, green, or foul-smelling fluid coming from the wound. A properly healing wound should not have significant discharge beyond a small amount of clear fluid.

Act quickly if: You notice pus, a bad odor, or an increase in drainage, as these are strong indicators of bacterial infection requiring immediate attention.

4. Increased Pain or Tenderness

Pain is expected after an injury, but it should gradually decrease over time. If your wound becomes more painful instead of improving, it may indicate an underlying issue like infection or delayed healing.

Red flag: If touching the wound becomes increasingly painful, or if discomfort spreads beyond the injury site, a doctor should assess the situation.

5. Fever or Chills

While mild fever (below 100°F/ 38°C) can be a part of the healing process, high fever or persistent fever may indicate a more serious issue. High grade fever can be the body trying to fight harmful bacteria, viruses or fungi that have invaded the wound. This requires immediate care as it can get worse very easily.

Seek urgent care if: You experience a fever over 100.4°F (38°C) or chills along with any of the other symptoms listed above.

Importance of Clean and Safe Wound Dressings

Using the right wound care products can significantly reduce the risk of infection and promote faster healing. Proper wound dressings help create a protective barrier, control moisture levels, and keep the wound environment clean.

Antimicrobial dressings help prevent bacterial growth and maintain a sterile healing environment.
Waterproof dressings protect against external contaminants while ensuring proper moisture balance.
Gentle adhesive tapes secure dressings in place without causing skin irritation, making them suitable for daily use.

When to Seek Medical Help

If you notice any of the above warning signs, don’t wait. Seeking medical attention early can prevent more serious complications and help ensure a smooth recovery.

Call your doctor if:

Your wound isn’t healing or worsens after a few days.
You notice spreading redness, pus, increased pain, or fever.
You have underlying health conditions (like diabetes) that may slow healing.

Your body is designed to heal, but sometimes wounds need extra care. By paying attention to these warning signs and using the right wound care products, you can prevent infections and support faster healing.

Taking action early can mean the difference between a quick recovery and serious complications. Stay safe, stay informed, and give your wound the care it deserves!

Chronic wounds are wounds that fail to heal within the expected time frame, typically lasting more than four weeks. They can arise due to underlying conditions such as diabetes, prolonged pressure, or venous insufficiency. Common types include diabetic ulcers, bed sores, and venous leg ulcers.

Managing chronic wounds presents significant challenges, including a high risk of infection, slow healing, and patient discomfort. The right dressing plays a crucial role in creating an optimal healing environment, reducing complications, and improving patient outcomes.

Types of Chronic Wounds and Their Dressing Needs

Diabetic Ulcers

A Diabetic foot ulcer is a debilitating complication of diabetes mellitus. It refers to an open sore or wound, commonly developing on the feet of people with diabetes.
Require moisture balance, infection control, and non-adhesive properties to protect fragile skin.

Bed Sores

Bed sores are ulcers which usually develop gradually on the skin and the tissue underneath. Occurring mostly in bed ridden patients, bed sores arise on the skin covering bony areas of the body such as hips, back, tailbone, etc.
Demand dressings that redistribute pressure and effectively manage exudate to prevent further skin breakdown.

Venous Leg Ulcers

Venous leg ulcers are chronic wounds affecting mostly older adults. They primarily result from prolonged venous insufficiency, which leads to tissue breakdown in lower extremities.
Benefit from a combination of compression therapy and absorbent dressings to address venous insufficiency and excessive fluid.

Infected Chronic Wounds

Chronic infected wounds are those wounds that do not even start to heal after 4 to 12 weeks despite treatment. They develop due to poor blood circulation, weak immune system or co-morbid conditions such as diabetes.
Require antimicrobial dressings to manage bacterial load and prevent further complications.

Key Dressing Options:

VEL NeXT™

Designed specifically for chronic wounds, including diabetic ulcers, burns, necrotizing fasciitis, and venous ulcers.
Promotes faster wound healing while maintaining an optimal moisture balance.

Velvert®

A secure antimicrobial dressing with excellent moisture management.
Ideal for wounds at high risk of infection, including diabetic ulcers and chronic wounds.

Silvel™

Features nano-crystalline silver for strong antimicrobial action.
Features silver for strong antimicrobial action.
Suitable for infected or high-risk wounds, particularly bed sores.

Velsap™

Designed for moderate to heavily exuding wounds.
Provides effective fluid management, reducing the need for frequent dressing changes.

How to Choose the Right Dressing?

Selecting the right dressing requires a comprehensive assessment of several factors:

Wound Type: Identify whether the wound is a diabetic ulcer, pressure sore, or venous ulcer.
Exudate Levels: Choose absorbent dressings for heavily exuding wounds and moisture-retaining options for dry wounds.
Infection Status: Use antimicrobial dressings for infected or high-risk wounds.
Patient-Specific Considerations: Factors such as mobility, skin sensitivity, and underlying health conditions must be considered.

Healthcare professionals play a crucial role in guiding dressing selection based on individual wound characteristics and patient needs.

Additional Tips for Chronic Wound Care Management

Proper Cleaning & Debridement: Keeping the wound clean and removing dead tissue enhances healing.
Regular Monitoring & Dressing Changes: Assessing the wound regularly and changing dressings at the right intervals prevent complications and ensure steady healing.

Chronic wounds require tailored solutions to support healing and prevent complications. Choosing the right dressing—ensures optimal wound care and faster recovery.

Explore our advanced dressing solutions today and find the best option for your wound care needs!

US Patent Granted for a Novel Herbal Dressing

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