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US Patent Granted For An Artificial Skin Substitute

Patent No.1: US 10, 004, 830 B2
Date of the Patent Granted: Jun. 26, 2018
Patent No.3: US 10, 149, 924 B1
Date of the Patent Granted: Dec. 11, 2018
Patent No.2: US 10, 098, 986 B1
Date of the Patent Granted: Oct. 16, 2018
Title of the Patent: READY TO USE BIODEGRADABLE AND BIOCOMPATIBLE ARTIFICIAL SKIN SUBSTITUTE AND A METHOD OF PREPARATION THEREOF

NEED OF THE INVENTION:

Wound Healing is a complex biological process. The main goal of the treatments is to achieve wound closure. In the cases of large wounds like burns, the availability of skin covers to repair the damaged areas is a problem. Different treatment modalities are available depending upon the type of the wound and the physician’s approach.

These may include surgical closure (primary intention), wound left open to close by a reparative process (secondary intention) or wound left open because of infection and closed surgically later (tertiary intention).

Since the primary goal is wound closure, the quality of healing is important because in the cases of deeper wounds the chances of infection and scar formation are very high.

Mesenchymal stem cells are progenitor cells of mesoderm origin. These were initially isolated from bone marrow. However, at present these can be isolated from the number of tissue niches including dental pulp, adipose tissue, umbilical cord, umbilical cord blood, skin, skeletal muscle etc. These are multipotent, immune-privileged cells, which can differentiate into multiple lineages including skin cells.

Therefore, they have been very instrumental in the field of regenerative medicine. Skin is the largest organ of the body and harbors stem cells within it which helps in repair. However, in the case of chronic wounds, the normal repair process gets delayed and it takes the very long time to heal.

This can be the result of various disorders like diabetic foot ulcer, severe burns, vasculitis etc. Chronic wounds cause substantial patient morbidity, with detrimental effects on patient quality of life, increasing pain, stress, depression, and social isolation.

Normal wound healing occurs in 3 stages:
1) Inflammation
2) Proliferation
3) Remodeling.

We @ Datt Mediproducts have developed a stem cell-based extracellular matrix for the treatment of burns, diabetic foot ulcer, and other chronic wounds. This matrix has tissue-like properties and can be used for wound healing. This patent describes the invention as well as the in-vitro method of cell-based skin substitute preparation.

ABOUT THE INVENTION:

The present invention provides a novel and unique technique of culturing of proliferating human mesenchymal stem cells on a biocompatible matrix membrane to form a confluent layer of cell sheet with secreted growth factors, suitable for grafting. This invention also provides a ready to use biodegradable and biocompatible tissue construct with autologous/allogeneic human stem cell-based product.

The innovative product has tissue-like properties and is a very effective, easy to use, cost-effective artificial skin substitute. The present invention uses proliferative/confluent Mesenchymal stem cells (MSCs), fibroblast, keratinocytes, and Mesenchymal stem cells differentiated fibroblast and keratinocytes whereby cells are transferred from culture to the wound bed.

This product not only helps to achieve satisfactory wound closure but also helps to restore functional integrity in the least time and with the least complications and morbidity.

Advantages of the Invention:
– Provides the support, growth factors and essential cytokines for wound healing.
– The scaffold of the present invention does not stick to the wound.
– The present invention comprises of improved wound and hygiene.
– It can be manufactured in any size and shape as per the requirement.
– Easy to handle.
– It can be removed easily.
– Environment friendly as it is degradable easily.
– It aids in wound healing.
– It ensures rapid healing of wound.
– It ensures moist wound environment by preventing wound desiccation.

The graft can be made within 15 days. It is an alternative treatment to the standard wound management therapies. There is a dramatically reduced risk of transmission of infectious disease due to rigorous process controls.

INTENDED USE:

Grafting to a patient with tissue or organ defect, such as skin ulcer or wound, or in vitro tissue testing or animal graftings such as for safety testing or validation of pharmaceutical, cosmetic, and chemical products.

Follow us @ Datt Mediproducts to know more about the company and product.

Visit www.dattmedi.com for more infomation.
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Medical tapes play a crucial role in the healthcare industry, providing essential support in wound care management and ensuring patient comfort and safety. These adhesive products are designed to secure dressings, medical devices, and other materials to the skin, facilitating the healing process and protecting patients from infections. In this blog post, we will explore the importance of medical tapes in healthcare, discuss the different types commonly used, delve into their role in wound care management, address patient comfort and safety concerns, and provide guidelines for their proper application and removal.

Importance of Medical Tapes in the Healthcare Industry:

Medical tapes are indispensable tools in the healthcare industry, offering numerous benefits for both healthcare professionals and patients. These tapes serve as an effective means of securing wound dressings, surgical incisions, and medical devices, such as catheters or IV lines. By keeping these materials in place, medical tapes promote proper healing, prevent contamination, and reduce the risk of infection. Moreover, they provide support to the injured area, minimizing movement and potential damage. The versatility and ease of use of medical tapes make them an essential component of any healthcare setting.

There is a wide range of medical tapes available, each designed to suit specific applications and patient needs. Some commonly used types include:

Minipore™:

Minipore™ tape is a hypoallergenic paper tape that offers gentle adhesion, making it suitable for patients with sensitive or fragile skin. It allows for breathability, reducing the risk of skin maceration while securely holding dressings in place. Read more about products visit https://dattmedi.com/minipore.html

Velpore™:

Velpore surgical paper tape possesses hypoallergenic qualities, making it ideal for individuals with sensitive skin or allergies. Its gentle nature ensures it is kind to the skin. The microporous structure of Velpore enables exceptional breathability, facilitating airflow and minimizing the likelihood of maceration.This tape is frequently utilized for securing wound dressings, delivering dependable fixation while enabling freedom of movement and flexibility. Its mild adhesive properties allow for painless and damage-free removal from the skin. Read more about products visit https://www.dattmedi.com/velpore.html

Velsilk™:

Velsilk tape is a silk-like cloth tape that combines excellent adhesion with gentle removal. It adheres securely to the skin while minimizing discomfort during tape removal. It is particularly useful in situations where frequent dressing changes are required, as it allows for easy application and removal. Read more about products visit https://www.dattmedi.com/velsilk.html

Role of Tapes in Wound Care Management:

Medical tapes play a vital role in wound care management. They help to secure dressings and keep them in place, preventing contamination and facilitating the healing process. Tapes also provide stability and support to the wound, reducing movement and minimizing the risk of further injury.

Additionally, they create a barrier against external pathogens, protecting the wound from infection. Properly applied medical tapes promote optimal wound healing and can contribute to positive patient outcomes.

Significance of Patient Comfort and Safety:

Patient comfort and safety are of utmost importance in healthcare. When using medical tapes, it is essential to consider the comfort and specific needs of each patient. The choice of tape should be based on factors such as skin sensitivity, wound location, and duration of use. It is crucial to select tapes that are hypoallergenic, breathable, and gentle on the skin to minimize the risk of adverse reactions. Regular monitoring of the taped area is necessary to ensure that the tape is not causing any discomfort or skin irritation. Moreover, proper tape removal techniques should be employed to avoid skin damage or pain.
Guidelines and Best Practices for Application and Removal:

To ensure the effective and safe use of medical tapes, the following guidelines should be followed:

  • Clean and dry the area before applying the tape.
  • Select an appropriate tape based on the patient’s needs and skin sensitivity.
  • Avoid excessive tension when applying the tape to prevent skin irritation.
  • Cut the tape to the desired length and shape, considering the wound size and location.
  • Ensure that the tape is firmly but comfortably secured, avoiding any wrinkles or folds.
  • Regularly assess the taped area for signs of skin irritation or discomfort.
  • When removing the tape, gently lift one corner and slowly peel it back, following the direction of hair growth to minimize pain and skin damage.
  • Apply the tape smoothly, avoiding excessive tension or wrinkling.
  • Periodically assess the tape’s integrity and reapply if necessary.
  • When removing the tape, gently lift the edges parallel to the skin while supporting the wound area to minimize pain and skin trauma.
  • If the tape is stubborn or adhered tightly, consider using a medical adhesive remover to aid in its removal.
  • After tape removal, clean the skin and assess for any signs of irritation or redness.

When properly applied and removed, medical tapes contribute to effective wound healing, prevent infection, and enhance patient comfort. By following guidelines for their proper application and removal, healthcare providers can maximize the benefits of medical tapes while minimizing the risk of complications.


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