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US Patent Granted for an Artificial Skin Substitute

Patent No.1: US 10, 004, 830 B2
Date of the Patent Granted: Jun. 26, 2018
Patent No.3: US 10, 149, 924 B1
Date of the Patent Granted: Dec. 11, 2018
Patent No.2: US 10, 098, 986 B1
Date of the Patent Granted: Oct. 16, 2018
Title of the Patent: READY TO USE BIODEGRADABLE AND BIOCOMPATIBLE ARTIFICIAL SKIN SUBSTITUTE AND A METHOD OF PREPARATION THEREOF

NEED OF THE INVENTION:

Wound Healing is a complex biological process. The main goal of the treatments is to achieve wound closure. In the cases of large wounds like burns, the availability of skin covers to repair the damaged areas is a problem. Different treatment modalities are available depending upon the type of the wound and the physician’s approach.

These may include surgical closure (primary intention), wound left open to close by a reparative process (secondary intention) or wound left open because of infection and closed surgically later (tertiary intention).

Since the primary goal is wound closure, the quality of healing is important because in the cases of deeper wounds the chances of infection and scar formation are very high.

Mesenchymal stem cells are progenitor cells of mesoderm origin. These were initially isolated from bone marrow. However, at present these can be isolated from the number of tissue niches including dental pulp, adipose tissue, umbilical cord, umbilical cord blood, skin, skeletal muscle etc. These are multipotent, immune-privileged cells, which can differentiate into multiple lineages including skin cells.

Therefore, they have been very instrumental in the field of regenerative medicine. Skin is the largest organ of the body and harbors stem cells within it which helps in repair. However, in the case of chronic wounds, the normal repair process gets delayed and it takes the very long time to heal.

This can be the result of various disorders like diabetic foot ulcer, severe burns, vasculitis etc. Chronic wounds cause substantial patient morbidity, with detrimental effects on patient quality of life, increasing pain, stress, depression, and social isolation.

Normal wound healing occurs in 3 stages:
1) Inflammation
2) Proliferation
3) Remodeling.

We @ Datt Mediproducts have developed a stem cell-based extracellular matrix for the treatment of burns, diabetic foot ulcer, and other chronic wounds. This matrix has tissue-like properties and can be used for wound healing. This patent describes the invention as well as the in-vitro method of cell-based skin substitute preparation.

ABOUT THE INVENTION:

The present invention provides a novel and unique technique of culturing of proliferating human mesenchymal stem cells on a biocompatible matrix membrane to form a confluent layer of cell sheet with secreted growth factors, suitable for grafting. This invention also provides a ready to use biodegradable and biocompatible tissue construct with autologous/allogeneic human stem cell-based product.

The innovative product has tissue-like properties and is a very effective, easy to use, cost-effective artificial skin substitute. The present invention uses proliferative/confluent Mesenchymal stem cells (MSCs), fibroblast, keratinocytes, and Mesenchymal stem cells differentiated fibroblast and keratinocytes whereby cells are transferred from culture to the wound bed.

This product not only helps to achieve satisfactory wound closure but also helps to restore functional integrity in the least time and with the least complications and morbidity.

Advantages of the Invention:
– Provides the support, growth factors and essential cytokines for wound healing.
– The scaffold of the present invention does not stick to the wound.
– The present invention comprises of improved wound and hygiene.
– It can be manufactured in any size and shape as per the requirement.
– Easy to handle.
– It can be removed easily.
– Environment friendly as it is degradable easily.
– It aids in wound healing.
– It ensures rapid healing of wound.
– It ensures moist wound environment by preventing wound desiccation.

The graft can be made within 15 days. It is an alternative treatment to the standard wound management therapies. There is a dramatically reduced risk of transmission of infectious disease due to rigorous process controls.

INTENDED USE:

Grafting to a patient with tissue or organ defect, such as skin ulcer or wound, or in vitro tissue testing or animal graftings such as for safety testing or validation of pharmaceutical, cosmetic, and chemical products.

Visit www.dattmedi.com for more infomation.

Velfour® is a revolutionary 4-layer compression bandaging system designed to manage venous leg ulcers and associated conditions. With a sub-bandage pressure of 35-40 mm Hg at the ankle, this high-compression system incorporates elastic layers to achieve sustained compression and promote healing.

Velfour® consists of four essential components that work together synergistically to deliver effective compression and support:

1. Velfour®#1 (Orthopaedic wool):

This layer serves as the primary absorbent material, effectively managing exudate while redistributing pressure evenly around the limb.

2. Velfour® #2 (Cotton crepe bandage):

Designed to enhance absorbency, the cotton crepe bandage smooths out the Orthopaedic Wool layer, ensuring optimal comfort and performance.

3. Velfour®#3 (Elastic Compression Bandage):

The first layer of elastic compression sub-bandage, exerting a pressure of approximately 17 mm Hg at the ankle. This layer provides the initial compression necessary for effective treatment.

4. Velfour® #4 (Cohesive Bandage):

The second layer of compression, adding the remaining 23 mm Hg of pressure while ensuring the bandage remains securely in place. The cohesive properties of this bandage contribute to its stability and adherence.

Velfour® offers a range of features and benefits that make it an exceptional choice for venous leg ulcer management:

1. Effective compression:

With a pressure of approximately 40 mm Hg at the ankle, it delivers the necessary compression to promote healing, gradually reducing to 17 mm Hg at the knee. This graduated compression approach ensures optimal therapeutic results.

2. Graduated compression:

The bandage provides high compression at the ankle and gradually decreases the pressure at the calf.

3. Sustained compression:

It maintains a consistent level of compression for up to a full week, allowing for uninterrupted therapy and reducing the frequency of bandage changes. The treatment process is made simpler by this feature, which also increases patient compliance.

The leading option for treating venous leg ulcers, Velfour® also has additional advantages for a number of other ailments, such as:

1. Treatment of Venous Ulcers:

It improves results by hastening the healing process and facilitating the closure of venous leg ulcers.

2. Prevention of Ulcer Recurrence:

In cases where traditional compression stockings are not tolerated, It provides an effective alternative for preventing the recurrence of venous ulcers.

3. Symptomatic Relief of Superficial Thrombophlebitis:

The compression offered by Velfour®alleviates pain and inflammation associated with superficial thrombophlebitis, providing much-needed comfort to patients.

4. Traumatic Wounds with Local Edema:

It aids in reducing edema and promoting the healing of traumatic wounds, helping to restore the affected area to its optimal state.

5. Venous/Lymphatic Disorders:

It is suitable for managing various venous and lymphatic disorders by providing effective compression and support.

To ensure the optimal application and use of Velfour®, it is essential to follow these guidelines:

1. Limb Assessment:

Accurate measurement of the ankle circumference is crucial to determine the appropriate combination of bandages needed. Any changes in limb contour should also be noted for reference.

2. Wound Assessment:

Mapping the ulcer provides a baseline to track progress throughout the treatment. Regular wound assessment enables healthcare professionals to evaluate the effectiveness of Velfour® and make necessary adjustments.

3. Pain Assessment:

This plays a crucial role in managing venous leg ulcers. Compression therapy with it can alleviate pain, although a slight increase may occur initially.

Velfour® stands as a game-changing solution for managing venous leg ulcers. Its innovative 4-layer compression bandage system, combined with its effective pressure distribution and sustained compression, offers unparalleled benefits for patients and healthcare professionals alike.

We are committed to providing valuable information and insights to support your journey towards improved wound healing and patient well-being.

Allergies are a common health issue that affect a significant portion of the population worldwide. Allergies are a hypersensitive reaction of the immune system to an otherwise harmless substance, which is known as an allergen. The allergen can be any substance that triggers an allergic reaction in the body, such as pollen, dust, food, or animal dander.

Allergies are caused due to the abnormal response of the immune system, which mistakes a harmless substance for a harmful invader and initiates a defence mechanism, called antibodies, to protect the body from it. This results in various allergic reactions, such as skin rashes, itching, sneezing, watery eyes, and in severe cases, anaphylaxis.

There are various reasons behind the occurrence of allergies. Genetics plays a significant role in determining an individual’s likelihood of developing allergies. Environmental factors such as exposure to pollution, chemicals, and toxins can also trigger allergies.

There are several different types of allergies, each with their unique symptoms and triggers.

Some of the most common types of allergies include:

1. Respiratory allergies:

These allergies are triggered by airborne allergens such as pollen, dust mites, and animal dander. The symptoms of respiratory allergies include sneezing, coughing, and wheezing.

2. Food allergies:

These allergies occur when the immune system reacts to certain foods, such as nuts, shellfish, and eggs. Symptoms of food allergies can range from mild itching, tingling in the mouth, hives, swelling of the lips, tongue, face or throat to more severe life-threatening anaphylaxis.

3. Skin allergies:

These allergies occur when the skin comes into contact with an allergen, such as certain fabrics, metals, or cosmetics. The symptoms of skin allergies include rashes, itching, and swelling.

4. Insect allergies:

These allergies occur when an individual is bitten or stung by an insect, such as bees or mosquitoes. The symptoms of insect allergies can range from mild itching to severe anaphylaxis.

5. Medicine allergies:

Medicine allergies are hypersensitive reactions of the immune system to certain medications. They can cause symptoms like skin rashes, itching, swelling, and in severe cases, difficulty breathing or anaphylaxis. It is important to communicate medicine allergies to healthcare providers to ensure safe and effective treatment.

Precautionary methods can be taken to manage allergies. Firstly, it is crucial to identify the allergen that triggers the allergic reaction. This can be done through various tests such as skin tests or blood tests. Once the allergen is identified, it is essential to avoid exposure to it. For example, individuals with food allergies must avoid eating the allergen-containing food.

Similarly, those with respiratory allergies must avoid exposure to airborne allergens, such as pollen or animal dander. If a person has a known severe allergy then they can also wear a medical alert bracelet, which lets others know that you have a serious allergy incase they are unable to communicate it.

Medications such as antihistamines, decongestants, and corticosteroids can be used to manage allergy symptoms. In severe cases, epinephrine injections may be required to manage anaphylaxis.

In addition to medication, several lifestyle changes can also help manage allergies. One of the most important being to try to reduce stress levels. While stress can’t trigger an allergic reaction it can make it worse if you are having one. When in stress your body releases hormones including histamine, which is a powerful chemical that leads to allergy symptoms thus making the reaction worse.

Allergies can significantly impact the lives of those who suffer from them. However, with proper management, it is possible to reduce the severity of allergy symptoms. If you suspect that you have an allergy, it is important to seek medical advice and get a proper diagnosis.

We advice to follow precautionary methods and working with a healthcare professional, that can help you manage allergies and improve your quality of life. Follow us for more such information.