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US Patent Granted For An Artificial Skin Substitute

Patent No.1: US 10, 004, 830 B2
Date of the Patent Granted: Jun. 26, 2018
Patent No.3: US 10, 149, 924 B1
Date of the Patent Granted: Dec. 11, 2018
Patent No.2: US 10, 098, 986 B1
Date of the Patent Granted: Oct. 16, 2018
Title of the Patent: READY TO USE BIODEGRADABLE AND BIOCOMPATIBLE ARTIFICIAL SKIN SUBSTITUTE AND A METHOD OF PREPARATION THEREOF

NEED OF THE INVENTION:

Wound Healing is a complex biological process. The main goal of the treatments is to achieve wound closure. In the cases of large wounds like burns, the availability of skin covers to repair the damaged areas is a problem. Different treatment modalities are available depending upon the type of the wound and the physician’s approach.

These may include surgical closure (primary intention), wound left open to close by a reparative process (secondary intention) or wound left open because of infection and closed surgically later (tertiary intention).

Since the primary goal is wound closure, the quality of healing is important because in the cases of deeper wounds the chances of infection and scar formation are very high.

Mesenchymal stem cells are progenitor cells of mesoderm origin. These were initially isolated from bone marrow. However, at present these can be isolated from the number of tissue niches including dental pulp, adipose tissue, umbilical cord, umbilical cord blood, skin, skeletal muscle etc. These are multipotent, immune-privileged cells, which can differentiate into multiple lineages including skin cells.

Therefore, they have been very instrumental in the field of regenerative medicine. Skin is the largest organ of the body and harbors stem cells within it which helps in repair. However, in the case of chronic wounds, the normal repair process gets delayed and it takes the very long time to heal.

This can be the result of various disorders like diabetic foot ulcer, severe burns, vasculitis etc. Chronic wounds cause substantial patient morbidity, with detrimental effects on patient quality of life, increasing pain, stress, depression, and social isolation.

Normal wound healing occurs in 3 stages:
1) Inflammation
2) Proliferation
3) Remodeling.

We @ Datt Mediproducts have developed a stem cell-based extracellular matrix for the treatment of burns, diabetic foot ulcer, and other chronic wounds. This matrix has tissue-like properties and can be used for wound healing. This patent describes the invention as well as the in-vitro method of cell-based skin substitute preparation.

ABOUT THE INVENTION:

The present invention provides a novel and unique technique of culturing of proliferating human mesenchymal stem cells on a biocompatible matrix membrane to form a confluent layer of cell sheet with secreted growth factors, suitable for grafting. This invention also provides a ready to use biodegradable and biocompatible tissue construct with autologous/allogeneic human stem cell-based product.

The innovative product has tissue-like properties and is a very effective, easy to use, cost-effective artificial skin substitute. The present invention uses proliferative/confluent Mesenchymal stem cells (MSCs), fibroblast, keratinocytes, and Mesenchymal stem cells differentiated fibroblast and keratinocytes whereby cells are transferred from culture to the wound bed.

This product not only helps to achieve satisfactory wound closure but also helps to restore functional integrity in the least time and with the least complications and morbidity.

Advantages of the Invention:
– Provides the support, growth factors and essential cytokines for wound healing.
– The scaffold of the present invention does not stick to the wound.
– The present invention comprises of improved wound and hygiene.
– It can be manufactured in any size and shape as per the requirement.
– Easy to handle.
– It can be removed easily.
– Environment friendly as it is degradable easily.
– It aids in wound healing.
– It ensures rapid healing of wound.
– It ensures moist wound environment by preventing wound desiccation.

The graft can be made within 15 days. It is an alternative treatment to the standard wound management therapies. There is a dramatically reduced risk of transmission of infectious disease due to rigorous process controls.

INTENDED USE:

Grafting to a patient with tissue or organ defect, such as skin ulcer or wound, or in vitro tissue testing or animal graftings such as for safety testing or validation of pharmaceutical, cosmetic, and chemical products.

Follow us @ Datt Mediproducts to know more about the company and product.

Visit www.dattmedi.com for more infomation.
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CHOOSING THE RIGHT DRESSING

Chronic wounds are wounds that fail to heal within the expected time frame, typically lasting more than four weeks. They can arise due to underlying conditions such as diabetes, prolonged pressure, or venous insufficiency. Common types include diabetic ulcers, bed sores, and venous leg ulcers.

Managing chronic wounds presents significant challenges, including a high risk of infection, slow healing, and patient discomfort. The right dressing plays a crucial role in creating an optimal healing environment, reducing complications, and improving patient outcomes.

Types of Chronic Wounds and Their Dressing Needs

Diabetic Ulcers

  • A Diabetic foot ulcer is a debilitating complication of diabetes mellitus. It refers  to an open sore or wound, commonly developing on the feet of people with diabetes.
  • Require moisture balance, infection control, and non-adhesive properties to protect fragile skin.

Bed Sores

  • Bed sores are ulcers which usually develop gradually on the skin and the tissue underneath. Occurring mostly in bed ridden patients, bed sores arise on the skin covering bony areas of the body such as hips, back, tailbone, etc.
  • Demand dressings that redistribute pressure and effectively manage exudate to prevent further skin breakdown.

Venous Leg Ulcers

  • Venous leg ulcers are chronic wounds affecting mostly older adults. They primarily result from prolonged venous insufficiency, which leads to tissue breakdown in lower extremities.
  • Benefit from a combination of compression therapy and absorbent dressings to address venous insufficiency and excessive fluid.

Infected Chronic Wounds

  • Chronic infected wounds are those wounds that do not even start to heal after 4 to 12 weeks despite treatment. They develop due to poor blood circulation, weak immune system or co-morbid conditions such as diabetes.
  • Require antimicrobial dressings to manage bacterial load and prevent further complications.

Key Dressing Options:

VEL NeXT™

  • Designed specifically for chronic wounds, including diabetic ulcers, burns, necrotizing fasciitis, and venous ulcers.
  • Promotes faster wound healing while maintaining an optimal moisture balance.

Velvert®

  • A secure antimicrobial dressing with excellent moisture management.
  • Ideal for wounds at high risk of infection, including diabetic ulcers and chronic wounds.

Silvel™

  • Features nano-crystalline silver for strong antimicrobial action.
  • Features silver for strong antimicrobial action.
  • Suitable for infected or high-risk wounds, particularly bed sores.

Velsap™

  • Designed for moderate to heavily exuding wounds.
  • Provides effective fluid management, reducing the need for frequent dressing changes.

How to Choose the Right Dressing?

Selecting the right dressing requires a comprehensive assessment of several factors:

  • Wound Type: Identify whether the wound is a diabetic ulcer, pressure sore, or venous ulcer.
  • Exudate Levels: Choose absorbent dressings for heavily exuding wounds and moisture-retaining options for dry wounds.
  • Infection Status: Use antimicrobial dressings for infected or high-risk wounds.
  • Patient-Specific Considerations: Factors such as mobility, skin sensitivity, and underlying health conditions must be considered.
Healthcare professionals play a crucial role in guiding dressing selection based on individual wound characteristics and patient needs.

Additional Tips for Chronic Wound Care Management

  • Proper Cleaning & Debridement: Keeping the wound clean and removing dead tissue enhances healing.
  • Regular Monitoring & Dressing Changes: Assessing the wound regularly and changing dressings at the right intervals prevent complications and ensure steady healing.

Chronic wounds require tailored solutions to support healing and prevent complications. Choosing the right dressing—ensures optimal wound care and faster recovery.

Explore our advanced dressing solutions today and find the best option for your wound care needs!

Applications of Velfix®࿯ T Film in Different Wound Types

Wound care has evolved significantly with the development of advanced dressings that cater to various needs. One such innovation is the Velfix® -T Film, a transparent film dressing made from high-quality polyurethane coated with adhesive on one side. This dressing offers a multitude of benefits, making it suitable for different wound types. In this blog, we will explore the various applications of Velfix® -T Film in wound management.

Waterproof Fixation of Wound Dressings:

One of the primary applications of Velfix® -T Film is its use as a waterproof fixation dressing. The film’s impermeability to liquid, water, and bacteria ensures that the wound remains protected from external contaminants. This feature is particularly beneficial for patients who need to shower or come into contact with water during their daily activities. The Velfix® -T Film acts as a barrier, keeping the wound dry and preventing infection while allowing moisture vapor and gases to pass through, promoting a healthy healing environment.

Managing Acute Wounds such as Abrasions and Lacerations:

Acute wounds, such as abrasions and lacerations, require prompt and effective management to prevent complications. Velfix® -T Film is an excellent choice for these types of wounds due to its flexibility and ease of application. The film conforms well to irregular wound contours, providing a secure and comfortable fit. Its transparent nature allows for easy monitoring of the wound’s progress without disturbing the healing process.

Using Velfix® -T Film for Postoperative Incisions:

Postoperative care involves protecting surgical incisions from infection and promoting optimal healing. Velfix® -T Film provides a protective barrier over postoperative wounds, reducing the risk of contamination while allowing for visual inspection without the need to remove the dressing. Its transparent nature facilitates monitoring of the wound site, ensuring early detection of any signs of infection or complications.

Protecting Minor Burns:

Minor burns can be painful and susceptible to infection. Velfix® -T Film offers a gentle and effective solution for protecting these wounds. Its hypoallergenic adhesive ensures secure fixation without causing discomfort, while the film’s barrier properties shield the burn from external irritants. The dressing also promotes a moist environment that supports faster healing and reduces scarring.

Benefits in Treating Superficial Pressure Ulcers:

Superficial pressure ulcers, often caused by prolonged pressure on specific areas of the body, require careful management to prevent further tissue damage. Velfix® -T Film‘s transparent and breathable design makes it ideal for these wounds. The dressing protects the ulcerated area from friction and trauma while allowing clinicians to monitor healing progress easily. Its moisture-retentive properties aid in promoting tissue regeneration and preventing infection.

Hence, Velfix® -T Film stands out as a versatile option in wound care, offering benefits across a range of applications. From waterproof fixation and postoperative wound management to protecting burns and treating pressure ulcers, this transparent film dressing provides a conducive environment for healing while ensuring patient comfort. Its ease of use, breathable design, and hypoallergenic properties make it a valuable tool in modern wound care practices.

Whether used in hospitals, clinics, or home care settings, Velfix® -T Film exemplifies innovation in wound management, enhancing patient outcomes and quality of care. For healthcare providers seeking reliable solutions to enhance wound healing, Velfix® -T Film proves to be an indispensable choice.