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US Patent Granted For An Artificial Skin Substitute

Patent No.1: US 10, 004, 830 B2
Date of the Patent Granted: Jun. 26, 2018
Patent No.3: US 10, 149, 924 B1
Date of the Patent Granted: Dec. 11, 2018
Patent No.2: US 10, 098, 986 B1
Date of the Patent Granted: Oct. 16, 2018
Title of the Patent: READY TO USE BIODEGRADABLE AND BIOCOMPATIBLE ARTIFICIAL SKIN SUBSTITUTE AND A METHOD OF PREPARATION THEREOF

NEED OF THE INVENTION:

Wound Healing is a complex biological process. The main goal of the treatments is to achieve wound closure. In the cases of large wounds like burns, the availability of skin covers to repair the damaged areas is a problem. Different treatment modalities are available depending upon the type of the wound and the physician’s approach.

These may include surgical closure (primary intention), wound left open to close by a reparative process (secondary intention) or wound left open because of infection and closed surgically later (tertiary intention).

Since the primary goal is wound closure, the quality of healing is important because in the cases of deeper wounds the chances of infection and scar formation are very high.

Mesenchymal stem cells are progenitor cells of mesoderm origin. These were initially isolated from bone marrow. However, at present these can be isolated from the number of tissue niches including dental pulp, adipose tissue, umbilical cord, umbilical cord blood, skin, skeletal muscle etc. These are multipotent, immune-privileged cells, which can differentiate into multiple lineages including skin cells.

Therefore, they have been very instrumental in the field of regenerative medicine. Skin is the largest organ of the body and harbors stem cells within it which helps in repair. However, in the case of chronic wounds, the normal repair process gets delayed and it takes the very long time to heal.

This can be the result of various disorders like diabetic foot ulcer, severe burns, vasculitis etc. Chronic wounds cause substantial patient morbidity, with detrimental effects on patient quality of life, increasing pain, stress, depression, and social isolation.

Normal wound healing occurs in 3 stages:
1) Inflammation
2) Proliferation
3) Remodeling.

We @ Datt Mediproducts have developed a stem cell-based extracellular matrix for the treatment of burns, diabetic foot ulcer, and other chronic wounds. This matrix has tissue-like properties and can be used for wound healing. This patent describes the invention as well as the in-vitro method of cell-based skin substitute preparation.

ABOUT THE INVENTION:

The present invention provides a novel and unique technique of culturing of proliferating human mesenchymal stem cells on a biocompatible matrix membrane to form a confluent layer of cell sheet with secreted growth factors, suitable for grafting. This invention also provides a ready to use biodegradable and biocompatible tissue construct with autologous/allogeneic human stem cell-based product.

The innovative product has tissue-like properties and is a very effective, easy to use, cost-effective artificial skin substitute. The present invention uses proliferative/confluent Mesenchymal stem cells (MSCs), fibroblast, keratinocytes, and Mesenchymal stem cells differentiated fibroblast and keratinocytes whereby cells are transferred from culture to the wound bed.

This product not only helps to achieve satisfactory wound closure but also helps to restore functional integrity in the least time and with the least complications and morbidity.

Advantages of the Invention:
– Provides the support, growth factors and essential cytokines for wound healing.
– The scaffold of the present invention does not stick to the wound.
– The present invention comprises of improved wound and hygiene.
– It can be manufactured in any size and shape as per the requirement.
– Easy to handle.
– It can be removed easily.
– Environment friendly as it is degradable easily.
– It aids in wound healing.
– It ensures rapid healing of wound.
– It ensures moist wound environment by preventing wound desiccation.

The graft can be made within 15 days. It is an alternative treatment to the standard wound management therapies. There is a dramatically reduced risk of transmission of infectious disease due to rigorous process controls.

INTENDED USE:

Grafting to a patient with tissue or organ defect, such as skin ulcer or wound, or in vitro tissue testing or animal graftings such as for safety testing or validation of pharmaceutical, cosmetic, and chemical products.

Follow us @ Datt Mediproducts to know more about the company and product.

Visit www.dattmedi.com for more infomation.
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Ensuring Safe Wound Care Practices

Wound care is a critical aspect of healthcare that demands meticulous attention to patient safety. Proper wound management not only accelerates healing but also significantly reduces the risk of complications. In this blog, we will explore the importance of patient safety in wound care, emphasizing best practices, infection control, and risk minimization.

Importance of Patient Safety in Wound Care

Patient safety in wound care involves implementing measures to prevent harm and ensure safety during the treatment process. This includes avoiding infections, minimizing pain, and ensuring that wounds heal properly. A safe wound care environment is essential for patient well-being and can prevent further medical complications.

Best Practices in Wound Care

Assessment and Planning:

  • Thorough Assessment: Begin with a comprehensive assessment of the wound, considering factors like wound type, exudate characteristics, comorbid conditions, pain level, periwound condition, size, depth, and location. Understand the patient’s overall health, including any underlying conditions that may affect healing.
  • Individualized Care Plan: Develop a tailored care plan that addresses the specific needs of the patient and the wound. Regularly update the plan based on the wound’s progress.

Hygiene and Infection Control:

  • Clean Environment: Ensure the wound care area is clean and sanitized. All reusable wound care equipment and supplies should be sterilized before use. Fresh dressings and bandages should be cut with clean apparatus.
  • Hand Hygiene: Proper hand hygiene is crucial. Perform hand hygiene using alcohol-based rub or soap and water immediately before and after the wound care procedure. The use of gloves and other personal protective equipment (PPE) is mandatory to prevent contamination.

Wound Cleaning and Dressing:

  • Gentle Cleaning: Clean the wound gently with saline solution or appropriate antiseptic solutions. Avoid harsh scrubbing which can damage tissue and impede healing.
  • Appropriate Dressings: Use the right type of dressing for the wound such as hydrocolloid dressings for pressure ulcers or alginate dressings for heavily exuding wounds. Change dressings as per the doctor’s care plan to maintain a clean environment.

Patient Education and Involvement:

  • Educate Patients: Instruct patients and caregivers on proper wound care techniques, signs of infection, and when to seek medical advice. Patient education enhances compliance and promotes faster healing.

Infection Control:

Preventing infections is a cornerstone of safe wound care. Infections can complicate wound healing and lead to serious health issues. Implementing stringent infection control measures is essential.

  • Sterile Techniques: Always use sterile wound care equipment and supplies when handling wounds. This includes using sterile dressings, tools, and gloves.
  • Regular Monitoring: Monitor the wound for signs of infection, such as increased redness, swelling, warmth, or discharge. Early detection and intervention can prevent severe complications.
  • Antibiotic Use: Use antibiotics judiciously. Overuse or not finishing the full course of the antibiotic can lead to antibiotic resistance, making infections harder to treat.

Minimizing Risks:

Risk minimization in wound care involves anticipating potential problems and taking steps to avoid them.

  • Nutrition and Hydration: Ensure patients have adequate nutrition and hydration. A proper diet supports tissue repair and overall health.
  • Pressure Ulcer Prevention: For bedridden patients, repositioning is crucial to prevent pressure ulcers. Use pressure-relieving devices like specialized mattresses or cushions.
  • Moisture Control: Keep the wound environment moist but not wet. Moisture balance prevents the wound from drying out or becoming too wet, both of which can impede healing.

Ensuring safe wound care practices is vital for promoting patient recovery and preventing complications. By adhering to best practices, maintaining strict infection control, and actively involving patients in their care, healthcare professionals can create a safe and effective wound care environment. As we strive for excellence in wound care, let us remember that patient safety is at the heart of healing.

Adhering to international standards like ISO 9001:2015 and ISO 13485:2016 while manufacturing wound care products can further enhance the quality of wound care practices, ensuring that products meet rigorous safety and quality benchmarks. Let us commit to delivering next-gen healing solutions with a steadfast focus on safety and patient well-being.

Advantages of Using Velfix®࿯ T+Pad for Post Surgical Wounds

In the field of post-surgical wound care, innovation plays a crucial role in ensuring optimal healing outcomes and patient comfort. Introducing Velfix® -T+Pad, a groundbreaking solution that redefines the standards of wound dressings. Meticulously designed and crafted, Velfix® -T+Pad stands at the forefront of advanced wound care technology, offering not only healing but also unparalleled comfort and convenience.

Waterproof and Bacterial Barrier Properties:

Among the essential features of wound dressings, waterproofing and bacterial barrier stand out. Velfix® -T+Pad not only meets these requirements but surpasses them. Its impermeable yet breathable film forms a protective shield against water and bacteria, safeguarding the wound from external threats and fostering a hygienic healing environment.

Benefits of Continuous Visual Monitoring: 

The advantage of transparent film dressings is the ability to visually monitor the wound without removing the dressing. This allows healthcare providers to detect early signs of infection: clinicians can quickly spot signs of infection, excessive drainage, or other complications, facilitating prompt intervention. It also aids in exudate management : ensuring that the wound exudate is being effectively absorbed and does not pose a risk to the healing process.

Conforming to Body Contours:

Comfort is paramount, especially in areas prone to movement or swelling. Velfix® -T+Pad addresses this need adeptly. Its flexible design seamlessly conforms to the body’s contours, providing a snug fit without compromising comfort. Whether it’s a joint, a curve, or a crease, Velfix® -T+Pad stays in place, ensuring uninterrupted healing.

Effective Evaporation of Moisture:

Moisture management is critical for wound healing, and Velfix® -T+Pad excels in this aspect. Thanks to its innovative adhesive pattern, it facilitates efficient moisture evaporation from the wound bed. This not only keeps the area dry but also prevents maceration, creating optimal conditions for healing.

Reducing Pain Upon Removal:

Dressing changes can be painful, but Velfix® -T+Pad aims to alleviate this discomfort. Featuring a non-adherent pad, it minimizes trauma upon removal, reducing pain and discomfort for the patient. With Velfix® -T+Pad, dressing changes become a smoother, more tolerable process, enhancing the overall patient experience.

In the realm of post-surgical wound care, excellence is imperative. With its innovative design and advanced technology, Velfix® -T+Pad sets a new standard for wound dressings, offering a comprehensive solution that prioritizes healing, comfort, and convenience. 

From its waterproof and bacterial barrier properties to its transparent film for easy monitoring, Velfix® -T+Pad epitomizes cutting-edge wound care. Trust in Velfix® -T+Pad to deliver not only healing but also peace of mind, ensuring a smoother, swiffer path to recovery for patients worldwide.

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