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US Patent Granted For A Novel Herbal Dressing


Patent No.: US 10, 076, 552 B2
Date of the Patent Granted: Sep. 18, 2018
Title of the Patent: MULTIFUNCTIONAL FORMULATION COMPRISED OF NATURAL INGREDIENTS AND METHOD OF PREPARATION MANUFACTURING THEREOF

What is Wound Healing & need of the Invention:
Wound Healing is a complex process in which the injured tissue is repaired & regenerated and new tissues are formed. The whole process involves three different phases: inflammation, proliferative and remodeling. Each of these phases is controlled and regulated by biologically active substances called growth factors.

These growth factors are hormone-like molecules that interact with specific cell surface receptors to control the process of tissue repair. The research shows that re-epithelialization is enhanced by the presence of occlusive wound dressings which maintain a moisture barrier.

There are different treatment modalities available for the treatment of wounds and ulcers ranging from antibiotics, occlusive layers, bandages, poultices, mechanical devices that reduce evaporation of water and many others.

The major drawback of these treatment methods is that they enhance wound healing by supporting the body mechanisms to heal the wound. If the patient will have compromised immunity or other body functions that may not work optimally, wound healing will not take place or will be delayed. This may limit the mobility of the patient and lower the quality of life.

There is a need of the treatment method which could actively regenerate the skin, dermis and epidermis. We @ Datt Mediproducts have developed an innovative herbal based antimicrobial dressing which reduce the microflora in wounds and actively promotes healing by stimulating stem cells that are present even in deep wounds and enhance the migration of fibroblast and keratinocytes and secretion of growth factors.

ABOUT THE INVENTION:
The invention involves polymer chemistry and herbal formulation preparation for the treatment of compromised tissues like infected wounds, burn wounds and ulcers in both humans and animals. It is used as a topical device for a range of indications including anti – cancer transdermal patch for melanoma therapy, superbugs infected tropical wounds and multiple sclerosis also.

The invention is composed of a water solubilized nano-sized formulation of a non-aqueous extract of phyto-pharmaceuticals, animal or synthetic biocompatible gel or on matrix coated or both.

 SUMMARY OF THE INVENTION:
The present invention provides a wound healing matrix comprising of a variety of natural ingredients, all working together in a synergistic way to promote wound healing by stimulating the stem cells. Stem cells have a great potential of cell division and are ultimately responsible for the homeostasis of steady state tissues.

Stem cells are normally slow cycling. However, there proliferation can be stimulated by certain growth factors. For example, cytokines such as Tumor Necrosis Factor (TNF), Epidermal Growth Factor (EGF), Transforming Growth Factor (TGF) and Interleukin-1 (IL-1) are believed to be useful.

The present invention consists of different herbs and synthetic biopolymers which are helpful in relieving pain, providing a soothing effect, and healing the wounds upon repeated use by providing a moist healing environment and stimulating the stem cells to regenerate the lost tissues.

The transdermal patch formulated with phytopharmaceutical preparation is intended for transdermal delivery system preferably for cancer therapy either individually or the combination.

Advantages of the Invention:

  • It provides a multi-purpose wound healing matrix with a bandage for compromised tissues viz. skin having wounds or melanoma.
  • Enhanced bioavailability of its individual components, working together in a synergistic way.
  • Another promising advantage of this phytopharmaceutical invention is that it displays minimal side effects in clinical applications of the drug.
  • Since the components in the formulation are from herbal / natural resources, it is very safe and eco – friendly and does not produce any adverse effect on the skin.

Following are the broad range of applications:

  • Anti-microbial
  • Anti-inflammatory
  • Analgesic
  • Antioxidant
  • Wound healing
  • Radiation poisoning
  • Modulates immunity
  • Biocompatible
  • Haemostatic
  • Nano based technology for drug releasing
  • Anti-cancer properties
  • Multiple sclerosis

Follow us @Datt Mediproducts to know more about such innovative patented.

Visit www.dattmedi.com for more infomation.
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CHOOSING THE RIGHT DRESSING

Chronic wounds are wounds that fail to heal within the expected time frame, typically lasting more than four weeks. They can arise due to underlying conditions such as diabetes, prolonged pressure, or venous insufficiency. Common types include diabetic ulcers, bed sores, and venous leg ulcers.

Managing chronic wounds presents significant challenges, including a high risk of infection, slow healing, and patient discomfort. The right dressing plays a crucial role in creating an optimal healing environment, reducing complications, and improving patient outcomes.

Types of Chronic Wounds and Their Dressing Needs

Diabetic Ulcers

  • A Diabetic foot ulcer is a debilitating complication of diabetes mellitus. It refers  to an open sore or wound, commonly developing on the feet of people with diabetes.
  • Require moisture balance, infection control, and non-adhesive properties to protect fragile skin.

Bed Sores

  • Bed sores are ulcers which usually develop gradually on the skin and the tissue underneath. Occurring mostly in bed ridden patients, bed sores arise on the skin covering bony areas of the body such as hips, back, tailbone, etc.
  • Demand dressings that redistribute pressure and effectively manage exudate to prevent further skin breakdown.

Venous Leg Ulcers

  • Venous leg ulcers are chronic wounds affecting mostly older adults. They primarily result from prolonged venous insufficiency, which leads to tissue breakdown in lower extremities.
  • Benefit from a combination of compression therapy and absorbent dressings to address venous insufficiency and excessive fluid.

Infected Chronic Wounds

  • Chronic infected wounds are those wounds that do not even start to heal after 4 to 12 weeks despite treatment. They develop due to poor blood circulation, weak immune system or co-morbid conditions such as diabetes.
  • Require antimicrobial dressings to manage bacterial load and prevent further complications.

Key Dressing Options:

VEL NeXT™

  • Designed specifically for chronic wounds, including diabetic ulcers, burns, necrotizing fasciitis, and venous ulcers.
  • Promotes faster wound healing while maintaining an optimal moisture balance.

Velvert®

  • A secure antimicrobial dressing with excellent moisture management.
  • Ideal for wounds at high risk of infection, including diabetic ulcers and chronic wounds.

Silvel™

  • Features nano-crystalline silver for strong antimicrobial action.
  • Features silver for strong antimicrobial action.
  • Suitable for infected or high-risk wounds, particularly bed sores.

Velsap™

  • Designed for moderate to heavily exuding wounds.
  • Provides effective fluid management, reducing the need for frequent dressing changes.

How to Choose the Right Dressing?

Selecting the right dressing requires a comprehensive assessment of several factors:

  • Wound Type: Identify whether the wound is a diabetic ulcer, pressure sore, or venous ulcer.
  • Exudate Levels: Choose absorbent dressings for heavily exuding wounds and moisture-retaining options for dry wounds.
  • Infection Status: Use antimicrobial dressings for infected or high-risk wounds.
  • Patient-Specific Considerations: Factors such as mobility, skin sensitivity, and underlying health conditions must be considered.
Healthcare professionals play a crucial role in guiding dressing selection based on individual wound characteristics and patient needs.

Additional Tips for Chronic Wound Care Management

  • Proper Cleaning & Debridement: Keeping the wound clean and removing dead tissue enhances healing.
  • Regular Monitoring & Dressing Changes: Assessing the wound regularly and changing dressings at the right intervals prevent complications and ensure steady healing.

Chronic wounds require tailored solutions to support healing and prevent complications. Choosing the right dressing—ensures optimal wound care and faster recovery.

Explore our advanced dressing solutions today and find the best option for your wound care needs!

Applications of Velfix®࿯ T Film in Different Wound Types

Wound care has evolved significantly with the development of advanced dressings that cater to various needs. One such innovation is the Velfix® -T Film, a transparent film dressing made from high-quality polyurethane coated with adhesive on one side. This dressing offers a multitude of benefits, making it suitable for different wound types. In this blog, we will explore the various applications of Velfix® -T Film in wound management.

Waterproof Fixation of Wound Dressings:

One of the primary applications of Velfix® -T Film is its use as a waterproof fixation dressing. The film’s impermeability to liquid, water, and bacteria ensures that the wound remains protected from external contaminants. This feature is particularly beneficial for patients who need to shower or come into contact with water during their daily activities. The Velfix® -T Film acts as a barrier, keeping the wound dry and preventing infection while allowing moisture vapor and gases to pass through, promoting a healthy healing environment.

Managing Acute Wounds such as Abrasions and Lacerations:

Acute wounds, such as abrasions and lacerations, require prompt and effective management to prevent complications. Velfix® -T Film is an excellent choice for these types of wounds due to its flexibility and ease of application. The film conforms well to irregular wound contours, providing a secure and comfortable fit. Its transparent nature allows for easy monitoring of the wound’s progress without disturbing the healing process.

Using Velfix® -T Film for Postoperative Incisions:

Postoperative care involves protecting surgical incisions from infection and promoting optimal healing. Velfix® -T Film provides a protective barrier over postoperative wounds, reducing the risk of contamination while allowing for visual inspection without the need to remove the dressing. Its transparent nature facilitates monitoring of the wound site, ensuring early detection of any signs of infection or complications.

Protecting Minor Burns:

Minor burns can be painful and susceptible to infection. Velfix® -T Film offers a gentle and effective solution for protecting these wounds. Its hypoallergenic adhesive ensures secure fixation without causing discomfort, while the film’s barrier properties shield the burn from external irritants. The dressing also promotes a moist environment that supports faster healing and reduces scarring.

Benefits in Treating Superficial Pressure Ulcers:

Superficial pressure ulcers, often caused by prolonged pressure on specific areas of the body, require careful management to prevent further tissue damage. Velfix® -T Film‘s transparent and breathable design makes it ideal for these wounds. The dressing protects the ulcerated area from friction and trauma while allowing clinicians to monitor healing progress easily. Its moisture-retentive properties aid in promoting tissue regeneration and preventing infection.

Hence, Velfix® -T Film stands out as a versatile option in wound care, offering benefits across a range of applications. From waterproof fixation and postoperative wound management to protecting burns and treating pressure ulcers, this transparent film dressing provides a conducive environment for healing while ensuring patient comfort. Its ease of use, breathable design, and hypoallergenic properties make it a valuable tool in modern wound care practices.

Whether used in hospitals, clinics, or home care settings, Velfix® -T Film exemplifies innovation in wound management, enhancing patient outcomes and quality of care. For healthcare providers seeking reliable solutions to enhance wound healing, Velfix® -T Film proves to be an indispensable choice.